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EC number: 271-898-1 | CAS number: 68611-64-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-09-15 - 2008-10-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The GLP study was conducted according to an internationally accepted guideline. All study parameters are based on the specific guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Urea, reaction products with formaldehyde
- EC Number:
- 271-898-1
- EC Name:
- Urea, reaction products with formaldehyde
- Cas Number:
- 68611-64-3
- Molecular formula:
- not available
- IUPAC Name:
- Urea, reaction products with formaldehyde
- Test material form:
- other: liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- Standard dilution water was prepared just before the test by admixing 2.5 mL of stored solutions A, B, C and D into 1000 mL of distilled water.
A. 117.6 g CaCl2-2H20 in 1 L of distilled water
B. 49.3 g MgS04-7H20 in 1 L of distilled water
C. 25.9 g NaHC03 in 1 L of distilled water
D. 2.3 g KC1 in 1 L of distilled water
The dilution water should be of pH 7.8 ± 0.2. The sum of Ca + Mg ions should be approx. 2.5 mmol/L.
The stock solution of the test substance was prepared in the dilution water. 100 mg of the test substance was weighed into 1000 mL of the dilution water for preliminary test and 200 mg of the test substance was weighed into 1000 mL of the dilution water for limit test. The concentrations of solutions used in the preliminary and the limit test were obtained by dilution of the stock solution with dilution water.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna Straus were obtained by aperiodic parthenogenesis from own laboratory breeding. Daphnia were fed by a mixture of algae. The sensitivity of test species is periodically monitored by testing with the reference substance, potassium dichromate. The grow-up gravid females are separated into dilution water. Young daphnia born in 24 hours are segregated to the handling container from which they entered the experiment. At handling a care should be taken of not to penetrate the air under animal's shell.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 20±2°C
- pH:
- 7.8 - 8.0
- Dissolved oxygen:
- 8.4 - 8.5 mg/l
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 150 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 150 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 150 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- No immobilisation was observed in limit test. Therefore, exact values of EC5o could not be calculated and the values of EC are given in the form of a range. The NOEC and EC100 values are identified by direct observation.
Test results
24-hour EC5o > 150 mg/L
48-hour EC5o > 150 ing/L
24-hour NOEC - 150 mg/L
48-hour NOEC - 150 mg/L
24-hour EC100 > 150 mg/L
48-hour EC100 > 150 mg/L - Executive summary:
The test substance, Weikoform (Urea, reaction products with formaldehyde), was tested in acute immobilisation test on Daphnia magna. The test was performed according to EU method C.2 - Daphnia sp. Acute Immobilisation Test, Council Regulation (EC) No. 440/2008, published in O.J.L 142, 2008. The preliminary test was performed in range of test substance nominal concentrations 1-100 mg-L"'. Based on the no toxicity of the test substance found in preliminary test, the limit test was performed in appropriate concentration range. The analytical results showed that the test substance Weikoform (Urea, reaction products with formaldehyde) was stable in dilution water in conditions of the test. With regard to stability of the test substance the static test design was chosen. The limit test was performed in range of test substance nominal concentrations 61 - 150 mg/L. The nominal concentrations of the test substance were used for all evaluations and results.
Test results
24-hour EC5o > 150 mg/L
48-hour EC5o > 150 mg/L
24-hour NOEC - 150 mg/L
48-hour NOEC - 150 mg/L
24-hour EC100 > 150 mg/L
48-hour EC100 > 150 mg/L
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