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EC number: 700-857-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Sep. 25 to Oct. 23, 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP study conducted similarly to OECD guideline 301 F with deviations. No toxicity control was performed; however, the study “Activated sludge Respiration inhibition test (Monsanto study XX-91-71) shows that the test substance isn’t toxic to bacteria. This study is as a “toxicity control” for the biodeg study.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- yes
- Remarks:
- no toxicity control
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-hydroxy-4-(methylthio)butyric acid
- EC Number:
- 209-523-0
- EC Name:
- 2-hydroxy-4-(methylthio)butyric acid
- Cas Number:
- 583-91-5
- Molecular formula:
- C5H10O3S
- IUPAC Name:
- 2-hydroxy-4-(methylthio)butanoic acid
- Reference substance name:
- Hydroxy-2-methylthio-4-butanoic acid
- IUPAC Name:
- Hydroxy-2-methylthio-4-butanoic acid
- Details on test material:
- - Name of test material (as cited in study report): ALIMET
- Physical state: Light brown liquid
- Analytical purity: ≥ 88%
- Theoretical oxygen demand (ThOD): 1.49 mg O2/mg active
- Vapour pressure: 51-58% of vapour pressure of water at room temperature
- Density: 1.23 kg/L (20 °C)
- Water solubility: Infinite
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No data
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Mixed liquor was obtained from the aeration tank of the waste water treatment plant of Hasselt. This treatment plant was dealing predominantly with domestic sewage.
- Preparation of inoculum for exposure: Before use, the mixed liquor was sieved through a 0.5 mm sieve in order to remove large particles.
- Suspended solids content: 9.3 g/L - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 50 mg/L
- Based on:
- test mat.
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Test medium contains the following reagents per litre deionised water:
1 mL of the FeCl3 .6H2O solution
1 mL of the MgSO4.7H2O solution
1 mL of the CaCl2.2H2O solution
10 mL of the phosphate solution
- Test temperature: 20 ± 1 °C
- pH: pH of the test solutions at the end of the test was 7.0-7.8
- pH adjusted: No
- Suspended solids concentration: 28 mg/L
TEST SYSTEM
- Culturing apparatus: Borosilicate glass Erlenmeyers (500 mL)
- Number of culture flasks/concentration: Two
- Method used to create aerobic conditions: Oxygen was generated by a pressure sensitive electrolytic oxygen generator by passage of a constant current (100 mA for 20 s) through the sulphuric acid/copper solution. This oxygen was then supplied to the incubation flask.
- Measuring equipment: Oxygen demand of each test sample was continuously measured using the Sapromat apparatus (Voith GmBh, Heidenheim, FRG)
- Details of trap for CO2 if used: CO2 produced was absorbed by sodalime pellets
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes, containing mixed liquor and dilution water
- Procedure control: Yes, containing reference substance (aniline) with inoculated medium
Reference substance
- Reference substance:
- aniline
- Remarks:
- 100 mg/L
Results and discussion
- Preliminary study:
- No data
- Test performance:
- No data
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 88
- Sampling time:
- 28 d
- Remarks on result:
- other: Initial concentration of the test material: 50 mg/L
- Parameter:
- % degradation (O2 consumption)
- Value:
- 91
- Sampling time:
- 28 d
- Remarks on result:
- other: Initial concentration of the test material: 100 mg/L
- Details on results:
- Initial test material concentration: 50 mg/L
- Oxygen uptake = 58 mg O2/L
- Intrinsic biochemical oxygen demand, BODi = 1.16 mg O2/mg test substance
- % biodegradation on Day 5: > 10%
- % biodegradation on Day 6: > 60%
- % biodegradation on Day 28 = 88%
Initial test material concentration: 100 mg/L
- Oxygen uptake = 119.5 mg O2/L
- Intrinsic biochemical oxygen demand, BODi = 1.195 mg O2/mg test substance
- % biodegradation on Day 6: > 10%
- % biodegradation on Day 9: > 60%
- % biodegradation on Day 28 = 91%
BOD5 / COD results
- Results with reference substance:
- - Oxygen uptake = 230 mg O2/L
- Intrinsic biochemical oxygen demand, BODi = 2.30 mg O2/mg aniline
- ThOD = 3.01 mg O2/mg
- % biodegradation (Day 7) > 60%
- % biodegradation (Day 28) = 76%
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- % degradation in reference material reached the pass levels by Day 14; oxygen uptake of inoculum blank was 8 mg O2/L; pH of the test solutions at the end of the test was 7.0-7.8. Toxicity control was not performed. However, the study “Activated sludge Re
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Under the test conditions, ALIMET was readily biodegradable.
- Executive summary:
A study was conducted to determine the ready biodegradability of alimet in an aerobic aqueous medium similarly to OECD Guideline 301 F and in compliance with GLP. The substance was tested at concentrations of 50 and 100 mg/L and the inoculum was activated sewage sludge, domestic. The degradation of the test material was assessed by the determination of the amount of oxygen consumed. The test treatments, inoculum blank and the reference (aniline) were measured in duplicates.
At 50 mg/L test concentration, greater than 10% biodegradation of the test substance was reached on Day 5 and greater than 60% biodegradation was reached on Day 6. Hence, the test material met the 10 day window requirement for ready biodegradability. On Days 28, the biodegradation was 88%.
At 100 mg/L test concentration, greater than 10% biodegradation of the test substance was reached on Day 6 and greater than 60% biodegradation was reached on Day 9. Hence, the test material met the 10 day window requirement for ready biodegradability. On Days 28, the biodegradation was 91%.
The reference material, aniline, reached greater than 10% biodegradation on Day 4 and greater than 60% on Day 7. Hence, it met the validity criteria for a reference material. Oxygen uptake of inoculum blank was 8 mg O2/L and pH of the test solutions at the end of the test was 7.0-7.8.
Under the test conditions, ALIMET was readily biodegradable.
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