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Diss Factsheets
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EC number: 938-793-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979-04-30 to 1979-05-14
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because it is an acceptable and a well-documented study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 24 hour exposure duration
- GLP compliance:
- not specified
Test material
- Reference substance name:
- #2 home heating oil (50% catalytically-cracked)
- IUPAC Name:
- #2 home heating oil (50% catalytically-cracked)
- Details on test material:
- - Name of test material: API #78-4, #2 home heating oil (50% cat)
-Substance type: petroleum distillation product composed of hydrocarbon chains
- Physical state: liquid
- Analytical purity: not provided by the sponsor
- Impurities (identity and concentrations): not reported
- Composition of test material, percentage of components: 50% virgin gas oil and 50% cracked gas oil
- Isomers composition: not reported
- Purity test date: not reported
- Lot/batch No.: not reported
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not provided by the sponsor
- Storage condition of test material: stored in Elar's test material storage room
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Pel-Freeze Farms, Inc.
- Age at study initiation: 4 months
- Weight at study initiation: 2 to 4 kilograms
- Housing: housed individually in stainless steel cages with grated bottoms
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light):
IN-LIFE DATES: From: To:
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- Animals were observed at 24 and 72 hours and 7 and 14 days
- Number of animals:
- three males and three females
- Details on study design:
- TEST SITE
- Area of exposure: four test sites located lateral to the midline of the back (two sites on each side)
- % coverage: not reported
- Type of wrap if used: Saran Wrap, Band-Aid, and Conform elastic tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): excess test material was wiped off the skin with dampened gauze sponges
- Time after start of exposure: 24 hours
SCORING SYSTEM: scored using the Draize technique
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks:
- 14 days
- Remarks on result:
- other: intact skin
- Irritant / corrosive response data:
- Both erythema and oedema were observed at the 24 hour, 72 hour, and 7 day recording periods. By day 14 no signs of oedema and erythema were observed.
- Other effects:
- During the 14 day observation period hair did not regrow on the test sites, but grew normally on the surrounding skin.
Any other information on results incl. tables
Table 1: Average dermal irritation scores
|
24 hours |
72 hours |
7 days |
14 days |
||||
Erythema |
Oedema |
Erythema |
Oedema |
Erythema |
Oedema |
Erythema |
Oedema |
|
Abraded |
1.58 |
0.75 |
3.08 |
1.92 |
2.75 |
1.50 |
0 |
0 |
Intact |
1.58 |
0.83 |
3.42 |
2.17 |
2.75 |
1.42 |
0 |
0 |
Primary Irritation Score: 3.83
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The mean erythema and oedema scores during the 24 to 72 hour observation periods were 2.5 and 1.5, respectively. Based on the conditions of this study, the test substance is considered an irritant.
- Executive summary:
In a skin irritation study New Zealand White rabbits (3/sex) were tested with #2 Home Heating Oil (50% cat]) a substance composed of vacuum gas oils/hydrocracked gas oils/distillate fuels. The rabbits were exposed to 0.5 mL of test substance applied to four shaved test area on the back (2 abraded and 2 intact) via a a gauze patch. Gauze patches were secured with Saran wrap and Band-Aids and wrapped with Conform elastic tape. After 24 hours of exposure the covering were removed and the test sites were wiped with gauze sponges to removed excess material. Animals were observed at 24 hours, 72 hours, 7 and 14 days post-administration. Signs of erythema and eodema were scored according to the draize technique.
Signs of erythema and oedema were evident at 24 hours, 72 hours, and 7 days. By day 14 all erythema and oedema had subsided. The mean erythema and oedema scores during the 24 to 72 hour observation periods were 2.5 and 1.5, respectively. Based on the conditions of this study, the test material is classified as an irritant.
This study received a Klimisch score of 2 and is classified as reliable with restrictions because it is an acceptable and a well-documented study report.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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