Registration Dossier
Registration Dossier
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EC number: 700-672-1 | CAS number: 70226-26-5
Endpoint summary
Administrative data
Description of key information
Additional information
The ecotoxicity of Reaction products of
lauric acid and oxybis(propanediol) (List No. 700-672-1) was assessed by
QSAR calculations for its main component Diglycerol monolaurate using
the valid estimation tool ECOSAR v1.00. Diglycerol monolaurate
represents the major constituent of Reaction
products of lauric acid and oxybis(propanediol) (List No. 700-672-1).
Since this constituent is also the "soluble" ester compound of this UVCB
substance, it is considered to be appropriate for assessing the aquatic
toxicity in terms of a "worst case scenario".
Short-term toxicity values (EC50, LC50) for three trophic levels (algae, invertebrate, fish) were calculated to be in the range of 12.99 to 33.03 mg/L, with algae demonstrating to be the most sensitive organism group in acute tests. These results indicate that Reaction products of lauric acid and oxybis(propanediol) exhibits only a low acute toxicity to aquatic life.
Chronic values (ChV) calculated for fish and daphnids showed a 32d-ChV for fish of 1.32 mg/L and a 21d-ChV for daphnids of 17.19 mg/L. On the basis of these result the test substance is considered to have a moderate long term toxicity to fish. However, as the Chronic Value (ChV) does not directly correspond to the NOEC value needed for the PNEC derivation, the PNECs were calculated using the short-term toxicity values.
The calculated data for aquatic organisms and the assumed ready biodegradability indicate little or no concern for microorganisms in sewage treatment plants. Nevertheless, some experimental studies will soon be available on a similar substanceand thus will be addressed as part of a dossier update.
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