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Diss Factsheets
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EC number: 217-443-2 | CAS number: 1852-17-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Cyclic Urea and Thiourea Derivatives as Inducers of Murine Erythroleukemia Differentiation
- Author:
- Li, C.-d. et al.
- Year:
- 1 981
- Bibliographic source:
- J. Med. Chem. 24, 1089-1092
Materials and methods
- Principles of method if other than guideline:
- Cyclic urea and thiourea derivatives were compared to Me2SO and to tetramethylurea as inducers of the differentiation of murine erythroleukemia cells; concurrently, their effects on cellular replication were measured. These measurements were accomplished by exposing exponentially growing murine erythroleukemia cells to a wide range of concentrations of each agent to determine the optimal level required for maximum differentiation. The degree of erythroid maturation was measured by assessing the proportion of benzidine-positive cells (i .e., hemoglobincontaining cells) 6 days after continuous exposure to the agent under test. Cell numbers were determined on days 3 and 6 of incubation.
- GLP compliance:
- no
- Type of method:
- in vitro
- Endpoint addressed:
- other: cell replication and differentiation
Test material
- Reference substance name:
- Propyleneurea
- IUPAC Name:
- Propyleneurea
Constituent 1
Administration / exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
4 mM
Basis:
nominal conc.
Results and discussion
- Details on results:
- Propyleneurea did not inhibit cell growth. 15% of the cells were benzidine-positive after incubation with propyleneurea, indicating that propyleneurea was a relatively weak inducer of differentiation in this assay.
Any other information on results incl. tables
Effects of Propyleneurea on the Replication and Erythroid Differetiation of Friend Leukemia Cells:
Test substance |
Concentration, mM |
% cell growth on day 3a |
% cell growth on day 6a |
benzidine-positive cells, % |
Propyleneurea |
4 |
124 |
121 |
15 |
Me2SOb |
105 |
70 |
120 |
75 |
Me2SOb |
210 |
72 |
110 |
94 |
a Percent of untreated control cell growth.b Me2SO was included as a control in all experiments.
Applicant's summary and conclusion
- Conclusions:
- Propyleneurea did not inhibit cell growth and was a relatively weak inducer of differentiation in this assay using Friend Murine Erythrolekemia cells.
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