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EC number: 225-059-1 | CAS number: 4635-59-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound 4-chlorobutyryl chloride: No data available.
Hydrolysis product 4-chlorobutyric acid: No data available.
Because there are no data available for the parent compound and its hydrolysis product, the short-term toxicity to aquatic invertebrates is assessed on the results of the structurally similar substance isobutyric acid (weight-of-evidence approach).
Isobutyric acid: Acutely harmful to aquatic invertebrates.
Hydrolysis product HCL: Acutely very toxic for aquatic invertebrates (pH-dependent).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 51.25 mg/L
Additional information
Parent compound 4 -chlorobutyryl chloride and hydrolysis product 4 -chlorobutyric acid:
No data are available for 4 -chlorobutyryl chloride (CAS 4635 -59 -0). The substance rapidly decomposes in water and form HCl (CAS 7647 -01 -0) and 4 -chlorobutyric acid (CAS 627 -00 -9). No experimental data are available for both substances, therefore the short-term toxicity to aquatic invertebrates is assessed on the basis of a weight-of-evidence approach which considers is based on the analogue substances 3 -chloropropionic acid (CAS 107 -94 -8), butyric acid (CAS 107 -92 -6) and isobutyric acid (CAS 79 -31 -2).
3 -Chloropropionic acid:
The available data are not valid. The short-term toxicity to Daphnia magna was tested after 24 h of exposure instead of 48 h, which is the standard exposure according to recent guidelines. Nevertheless, the data will be used in a weight-of-evidence approach to demonstrate the pH-influence of the acid on the mobility of the Daphnids. The 24 -h EC50 was determined to be 109 mg/L. After neutralisation the 24 -h EC50 was 1366 mg/L (Trénel & Kühn, 1982).
Butyric acid:
For butyric acid no valid experimental data are available. Results as cited in Onitsuka et al. (1989) and Bringmann & Kuhn (1982) are not suitable since exposure duration is 24h instead of 48h. Nevertheless, the study of Bringmann & Kuhn can be used to show that the toxicity of butyric acid to Daphnia magna is likely influenced by pH effects due to pH-shift. Tested under not neutralized conditions the observed 24 -h EC50 was determined to be 55 mg/L. When the test medium was neutralized the obtained 24 -h EC50 was 1950 mg/L.
Isobutyric acid:
With the structurally similar substance isobutyric acid (CAS 79 -31 -2) the acute Daphnia toxicity was tested in a non-GLP study following the German Industrial Standard DIN 38412, part 11 (similar to OECD 202). The EC50 (48-h) was reported as 51.25 mg/L (BASF, 1989,1/0244/2/89-0244/89).
In a weight-of-evidence approach based on the results summmarised above, 4 -chlorobutyryl chloride and its hydrolysis product 4 -chlorobutyric acid are expected to be acutely not harmful to aquatic invertebrates after pH-adjustment. Nevertheless, the assessment will be based on the lowest valid EC50 of 51.25 mg/L.
Hydrolysis producthydrochloric acid (HCl):
The hydrolysis product hydrochloric acid (HCl) was tested in a semi-static acute toxicity test according to OECD 202 withDaphnia magna. The 48-h EC50was 0.492 mg/L (acid equivalent to pH 5.3; OECD, 2002).
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