Registration Dossier
Registration Dossier
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EC number: 619-599-0 | CAS number: 915095-94-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August - October 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD 423) and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- (3S)-3-{4-[(2-chloro-5-iodophenyl)methyl]phenoxy}oxolane
- EC Number:
- 619-599-0
- Cas Number:
- 915095-94-2
- Molecular formula:
- C17 H16 Cl I O2
- IUPAC Name:
- (3S)-3-{4-[(2-chloro-5-iodophenyl)methyl]phenoxy}oxolane
- Reference substance name:
- (S)-3-[4-(2-Chloro-5-iodobenzyl) phenoxy] tetrahydrofuran
- Cas Number:
- 915095-94-2
- Molecular formula:
- C17 H16 Cl I O2
- IUPAC Name:
- (S)-3-[4-(2-Chloro-5-iodobenzyl) phenoxy] tetrahydrofuran
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0,5% hydroxyethylcellulose (HEC) in deionized water
- Doses:
- 300mg/kg and 2000mg/kg
- No. of animals per sex per dose:
- 300mg/kg : 3 male and 3 female; starting dose
2000mg/kg : 3 male and 3 female - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 - <= 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed in any of the animals at 300 or 2000mg/kg.
- Clinical signs:
- other: No clinical signs were observed in the animals at 300 or 2000mg/kg.
- Gross pathology:
- No visible lesions were observed in any of the animals at 300 or 2000 mg/kg at terminal necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- According to the GHS system, IN00078283 adminstered orally at dose levels of 300 and 2000 mg/kg body weight in male and female rats was considered to be a Category 5 test substance with an LD50 greater than 2000-5000 mg/kg.
- Executive summary:
No mortality was observed in animals at 300 or 2000 mg/kg. No clinical signs were observed in the animals at 300 or 2000 mg/kg. All animals at 300 and 2000 mg/kg gained weight throughout the study. No visible lesions in any of the animals at 300 or 2000 mg/kg at terminal necropsy.
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