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EC number: 700-073-5 | CAS number: 1215036-04-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Stability in organic solvents and identity of relevant degradation products
Administrative data
- Endpoint:
- stability in organic solvents and identity of relevant degradation products
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 2009 - january 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: In compliance with GLP guidance
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Good Laboratory Practice Standards (Directive 2004/10/EC)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Isosorbide Diesters
- EC Number:
- 700-073-5
- Cas Number:
- 1215036-04-6
- Molecular formula:
- As it is an UVCB, we can not provide the exact molecular formula.
- IUPAC Name:
- Isosorbide Diesters
- Details on test material:
- Identification DIESTER D'ISOSORBIDE
Identification of the flask ROQUETTE Diester d'isosorbide, lot Fal/07/25,
LAB. 3822, Réf. 806297
Batch Fal 07/25
Expiry date Not provided
Supplier ROQUETTE FRERES
Appearance Colourless limpid liquid
Packaging 1 white plastic flask
1 transparent soft plastic flask
Quantity received 1 x 1.2 L
1 x 3 kg
Date of the reception 30 May 2007 and 09 July 2008
Storage in darkness at room temperature
Identification number for the study 07-066
Constituent 1
Results and discussion
- Test substance stable:
- yes
Applicant's summary and conclusion
- Conclusions:
- The test item was considered to be stable.
- Executive summary:
CHEMICAL STABILITY IN DIFFERENT SOLVENTS
The objective of the test is to determine the chemical stability of the test item in different solvents.
The chemical stability of the diester d’isosorbide is studied in four solvents which are petroleum ether, diisopropylether, ethanol and methanol.
An analytical quantification is done in the samplings issued from the degradation study. The isosorbide diesters is analysed as a silyl derivative by gas chromatography using a FID detector. Methyl-alpha-D-glucopyranoside is used in order to normalize the quantification.
Conclusion:
Before the storage procedure for 28 days at 30 ± 0.5 °C
The content of diester d’isosorbide in methanol was: 85.5 mg/L
The content of diester d’isosorbide in diisopropylether was: 82.8 mg/L
The content of diester d’isosorbide in petroleum ether was: 82.9 mg/L
The content of diester d’isosorbide in ethanol was: 84.3 mg/L
After the storage procedure for 4 days at 30 ± 0.5 °C
The content of diester d’isosorbide in methanol was: 81.9 mg/L
After the storage procedure for 8 days at 30 ± 0.5 °C
The content of diester d’isosorbide in methanol was: 87.9 mg/L
The content of diester d’isosorbide in diisopropylether was: 91.1 mg/L
The content of diester d’isosorbide in petroleum ether was: 86.9 mg/L
The content of diester d’isosorbide in ethanol was: 86.5 mg/L
After the storage procedure for 14 days at 30 ± 0.5 °C
The content of diester d’isosorbide in methanol was: 79.6 mg/L
The content of diester d’isosorbide in diisopropylether was: 91.0 mg/L
The content of diester d’isosorbide in petroleum ether was: 90.9 mg/L
The content of diester d’isosorbide in ethanol was: 83.5 mg/L
After the storage procedure for 28 days at 30 ± 0.5 °C
The content of diester d’isosorbide in methanol was: 83.5 mg/L
The content of diester d’isosorbide in diisopropylether was: 83.3 mg/L
The content of diester d’isosorbide in petroleum ether was: 84.0 mg/L
The content of diester d’isosorbide in ethanol was: 81.8 mg/L
No significant change was observed in the content of diester d’isosorbide in the four solvents after the storage procedure for 28 days at 30 ± 0.5 °C. The test item was considered to be stable.
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