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Diss Factsheets
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EC number: 204-485-1 | CAS number: 121-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
Data source
Reference
- Reference Type:
- other: Weight of evidence
- Title:
- Toxicokinetics
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- Based on the weight of evidence of various phys chem and bioaccumulative parameters in the dossier
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Based on the weight of evidence of various phys chem and bioaccumulative parameters in the dossier
- GLP compliance:
- no
Test material
- Reference substance name:
- N-acetylsulphanilyl chloride
- EC Number:
- 204-485-1
- EC Name:
- N-acetylsulphanilyl chloride
- Cas Number:
- 121-60-8
- Molecular formula:
- C8H8ClNO3S
- IUPAC Name:
- 4-acetamidobenzenesulfonyl chloride
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): N-acetylsulphanilyl chloride
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- other: unspecified
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: estimation
- Vehicle:
- unchanged (no vehicle)
- Control animals:
- not specified
Results and discussion
- Preliminary studies:
- Based on the results of dermal toxicokinetics it can be stated that the substance will have low absorption capability similar to as shown in dermal absorption, according to which the Danish (Q)SAR dermal absorption of N-acetyl sulphanilyl chloride is 0.00200 (Low).This value indicates low dermal absorption.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The Danish EPA database indicates the dermal absorption potential of N-acetylsulphanilyl chloride to be low (0.00200 mg/cm2/event). Also considering the particle size of the chemical as well as the low vapour pressure (0.0000446 Pa at 25°C), absorption by the inhalation route is expected to be low. There is a possibility of absorption by the gastro-intestinal tract upon oral intake of the chemical; as part of the sulpha drugs. The chemical is known to be moderately toxic by ingestion, if administered in high dose levels
- Details on distribution in tissues:
- There are reports that suggest decomposition of N-acetylsulphanilyl chloride in water. Considering the high solubility of the chemical N-acetylsulphanilyl chloride in organic solvents, the chemical is likely to be distributed in the lipid fraction of the living system.
- Details on excretion:
- The bio-concentration factor of -acetylsulphanilyl chloride is very low and ranges between the value 8.06 – 14.79. Also, the Log Kow value is < 3. These facts suggests that the chemical is unlikely to bio-accumulate within the living system after absorption and distribution. Normally the chemicals that do not bio-accumulate within the living systems are rapidly eliminated either through the urine, bile or faeces. Fat soluble (organic medium) chemicals may be conjugated and excreted in bile (faeces).
Metabolite characterisation studies
- Details on metabolites:
- There are no details available on the possible metabolites of the chemical N-acetylsulphanilyl chloride.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: low bioaccumulation potential based on study results
In case the substance,N-acetyl sulphanilyl chloride, is absorbed (though in small quantity) it will not be accumulated in the body. This is supported by the fact that the substance have not only low BCF value but alos have a moderate level of Kow which will support the reasoning that though the substance will enter the body but will get distributed through the lipid in the body. - Executive summary:
Based upon the physico-chemical properties of N-acetylsulphanilyl chloride, and comparing then with the general toxico-kinetic features; it can be predicted that the bio-accumulation potential of the chemical is expected to be low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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