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Diss Factsheets
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EC number: 272-940-1 | CAS number: 68921-45-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study not conducted in compliance with GLP, however, data included in SIDS OECD works as supporting information.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: SIDS DOSSIER DATA
- Title:
- Unnamed
- Year:
- 1 953
- Report date:
- 1953
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 25 males and 25 females volunteers were used in this study. 13 of each sex were African Americans and 12 of each sex were Caucasians selected for considerable suntan to facilitate the assessment of depigmentation potential. The test material was applied to identical spots on the backs of the volunteers for 24-hours every other day for 15 applications. Two weeks after the induction period the sites were challenged with the test material for 24-hours. Reactions were evaluated when the patches were removed.
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzenamine, N-phenyl-, reaction products with styrene and 2,4,4-trimethylpentene
- EC Number:
- 272-940-1
- EC Name:
- Benzenamine, N-phenyl-, reaction products with styrene and 2,4,4-trimethylpentene
- Cas Number:
- 68921-45-9
- Molecular formula:
- Variable; substance is a UVCB
- IUPAC Name:
- Reaction products of N-Phenylbenzenamine with styrene and 2,4,4-trimethylpentene
- Test material form:
- liquid: viscous
- Details on test material:
- Referenced only as BFGoodrich Material No. 2 (Stalite) , purity: Unknown, although detailed as CAS 68921-45-9 in the relevant section of the OECD SIDS report.
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- 25 males and 25 females volunteers were used in this study. 13 of each sex were African Americans and 12 of each sex were Caucasians selected for considerable suntan to facilitate the assessment of depigmentation potential.
- Clinical history:
- Not specified
- Controls:
- Not specified
- Route of administration:
- dermal
- Details on study design:
- The test material was applied to identical spots on the backs of the volunteers for 24-hours every other day for 15 applications. Two weeks after the induction period the sites were challenged with the test material for 24-hours. Reactions were evaluated when the patches were removed.
Results and discussion
- Results of examinations:
- A minimal transitory reaction was noted in 3 males and 4 females; these were considered insignificant and minimal. No depigmentation was noted.
The material was considered not to be a primary irritant, fatiguing agent or sensitizer
Applicant's summary and conclusion
- Conclusions:
- A minimal transitory reaction was noted in 3 males and 4 females; these were considered insignificant and minimal. No depigmentation was noted.
The material was considered not to be a primary irritant, fatiguing agent or sensitizer - Executive summary:
A minimal transitory reaction was noted in 3 males and 4 females; these were considered insignificant and minimal. No depigmentation was noted. The material was considered not to be a primary irritant, fatiguing agent or sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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