Phenethyl acetate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Limited methodology but sufficient for the purposes of hazard classication

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Ten rats dosed orally at 5000 mg/kg and observed for 14 days. No methodology details available in single page summary report. It is unclear whether males and females were used or a single sex.

GLP compliance:

not specified

Remarks:

study conducted prior to adoption of GLP principles

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Phenethyl acetate

EC Number:

203-113-5

EC Name:

Phenethyl acetate

Cas Number:

103-45-7

Molecular formula:

C10H12O2

IUPAC Name:

2-phenylethyl acetate

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No information available

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

No information available

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

Ten rats treated but report does not specify whether either or both sexes were used.

Control animals:

no

Details on study design:

Ten rats dosed orally at 5000 mg/kg bw and observed for mortality and clinical signs.

Statistics:

Not required for evaluation of results at the limit dose level

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

5 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% mortality at the limit dose level of 5000 mg/kg bw

Mortality:

Five of the ten rats died. Three were dead on observation day 1 (presumed to be the day of dosing) and one further death occurred on each of days 2 and 3.

Clinical signs:

other: Piloerection and loss of righting reflex were observed but no details available to indicate whether these were ante-mortem signs restricted to decedents, common signs observed in all rats or infrequent observations. No information on onset or recovery fro

Gross pathology:

No data

Other findings:

No data

Any other information on results incl. tables

No additional information

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Five of the ten rats dosed orally with phenyl ethyl acetate at 5000 mg/kg bw died within 3 days of administration.

Executive summary:

Ten rats were dosed orally with phenyl ethyl acetate at 5000 mg/kg bw and observed daily for mortality and clinical signs of reaction to treatment. No methodology details are provided in the report. Five rats died within 3 days of administration. Pilo-ercection and loss of righting reflex were observed although no details relating to when, how frequently or whether the signs were reversible or only seen as ante-mortem effects are recorded. The LD50 value is therefore approximately 5000 mg/kg bw.