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Diss Factsheets
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EC number: 604-669-5 | CAS number: 149021-58-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1950-04-20 to 1950-06-15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report. Read across was performed with 2-ethylhexyl acrylate. Please refer to IUCLID section 13 for read across justification.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 950
- Report date:
- 1950
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List IV.
- Author:
- Smyth HF et al.
- Year:
- 1 951
- Bibliographic source:
- AMA Arch. Ind. Hyg. Occup. Med. 4: 119-122
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Range-finding toxicity test basically according to the method described by Smyth Jr. and Carpenter (1948).
Smyth HF Jr. and Carpenter CP (1948). J. Ind. Hyg. Toxicol. 30: 63-68 - GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl acrylate
- EC Number:
- 203-080-7
- EC Name:
- 2-ethylhexyl acrylate
- Cas Number:
- 103-11-7
- IUPAC Name:
- 2-ethylhexyl acrylate
- Test material form:
- other: liquid
- Details on test material:
- - Test substance: 2-ethylhexyl acrylate (CAS: 103-11-7)
- Chemical name: 2-propenoic acid, 2-ethylhexyl ester
- Analytical Purity: no data
- Density: 0.887 g/cm3 (DIN 51757, cited in EU RAR, 2005)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Type of wrap: impervious "Vinylite" sheeting
REMOVAL OF TEST SUBSTANCE
- Washing: yes
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied: 5.0 and 10.0 mL/kg bw, respectively
- Duration of exposure:
- 24 h
- Doses:
- 5.0 and 10.0 mL/kg bw (corresponding to 4435 and 8870 mg/kg bw)
- No. of animals per sex per dose:
- 8
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Test conditions and method according to Smyth HF Jr. and Carpenter CP (1948):
Penetration of rabbit skin was estimated by a technique closely akin to the one-day cuff method of Draize et al. (1944) using groups of at least 6 rabbits. The fur was removed from the entire trunk by clipping, and the dose was retained beneath an impervious plastic film. Dosages greater than 20 mL/kg bw could not be retained in contact with the skin. The animals were immobilized during the 24-hour contact period, after which the film was removed and the rabbits were caged for the subsequent 14-day observation period. In this study, 8 rabbits were dosed by introduction of the undiluted test substance under impervious "Vinylite" sheeting which covered their clipped trunks. The LD50 value was determined by Thompson's method. - Statistics:
- The LD50 value was determined by Thompson's method.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 7 522 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Original value: LD50 = 8.480 mL/kg
Based on a densitiy of 0.887 g/mL, LD50 = 7522 mg/kg bw.
3 of 4 rats died at 10 ml/kg and none at 5 ml/kg
3/4 animals succumbed to a dosage of 10 mL/kg bw (= 8870 mg/kg bw), and 4/4 survived 5.0 mL/kg bw (= 4435 mg/kg bw). The estimated LD50 calculated by Thompson's method after assuming 100 % mortality at 20 mL/kg and 100 % survival at 2.52 mL/kg bw was 8.48 mL/kg bw. - Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.