Methyltriphenylphosphonium bromide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

The study has not been conducted according to GLP and the recent OECD guidlines for acute toxicity. Some basic information such as sex, strain and housing conditions as well as batch of the test material are not available in the report. But based on the available information the acute toxicity can be concluded.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

Principles of method if other than guideline:

From the report summary available it can not be established how many animals have been used per dose level and of which gender they have been.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Methyltriphenylphosphonium bromide

EC Number:

217-218-9

EC Name:

Methyltriphenylphosphonium bromide

Cas Number:

1779-49-3

Molecular formula:

C19H18P.Br

IUPAC Name:

methyl(triphenyl)phosphonium bromide

Test material form:

not specified

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

water

Doses:

Group 1: 1% in H2O: 25-400 mg/kg b.w.
Group 2: 10% in H2O: 50-800 mg/kg b.w.

No. of animals per sex per dose:

20 in Group 1 and 2, respectively

Control animals:

no

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

118 mg/kg bw

Based on:

test mat.

Remarks on result:

other: For the 1 % in H2O Solution

Effect levels 2

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

84 mg/kg bw

Based on:

test mat.

Remarks on result:

other: For the 10% in H2O Solution

Mortality:

Time of death: 2-24 h (1%) and 2.5-24h (10%)

Clinical signs:

other: 1% solution: 25-50 mg/kg: Diarrhea, normal activity 4-6 h. 100-400 mg/kg: Normal to prostrate diarrhea 10% solution: 50 mg/kg Slight to moderate wk., some diarrhea 2-4h, normal 24 h; 100 mg/kg: Moderate to severe wk., diarrhea 2-4h; 200-800 mg/kg: Tremors

Gross pathology:

not reported

Applicant's summary and conclusion

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

Result of LD50 is approx. 118 mg/kg b.w. when administered as 10% solution in water, and 84 mg/ kg b.w. when administered as 1% solution in water.