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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

The acute toxicity of Pyrrolidine to freshwater fish Danio rerio was determined in a GLP test according to OECD guideline 203 (BASF AG, 1993). Fish were exposed to the following nominal concentrations: control, 46.4, 100, 215, 464, 1000 and 1000* mg/L (* additional concentration was pH adjusted).
After 96 hours an LC50 for the endpoint mortality of 115 mg/L was estimated based on the mean measured concentration. All criteria for acceptability of the test were met according to OECD guideline No. 203 and the study is considered to be reliable with restrictions.
The department Environmental Research studied the acute toxicity for fish and the biodegradation in the aquatic environment according to guideline NEN-6504 (DSM, 1984). From the study it can be concluded that the nominal 96h-LC50 (Poecilia Reticulata) for pyrrolidine = 559 mg/L (95% confidence interval 430 - 688 mg/L).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
115 mg/L

Additional information

The acute toxicity of Pyrrolidine to freshwater fish was determined in two independent studies:

- a GLP test according to OECD guideline 203 (BASF AG, 1993)

- a non-GLP test according to guideline NEN-6504 (DSM, 1984)

The study conducted by BASF (1993) was chosen as the key study since it was performed according to OECD guideline 203 and under GLP, Furthermore, the reported LC50 was the lowest.