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EC number: 620-341-4 | CAS number: 61358-25-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 Dec 2011 - 08 Jan 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- THE DEPARTMENT OF HEALTH OF THE GOVERNMENT OF THE UNITED KINGDOM
Test material
- Reference substance name:
- bis(4-tert-butylphenyl)iodanium; hexafluoro-λ⁵-phosphanuide
- EC Number:
- 620-341-4
- Cas Number:
- 61358-25-6
- Molecular formula:
- C20H26F6IP
- IUPAC Name:
- bis(4-tert-butylphenyl)iodanium; hexafluoro-λ⁵-phosphanuide
- Details on test material:
- - Name of test material (as cited in study report): PF-6
- Physical state: white powder
- Analytical purity: 98.5%
- Purity test date: 2010-08-12
- Lot/batch No.: 20101020
- Expiration date of the lot/batch: 2012-04-12
- Storage condition of test material: at room temperature in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand White (Hsdlf:NZW)
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK Ltd., Leicestershire, UK
- Age at study initiation: 12-20 weeks
- Weight at study initiation: 2.56-2.80 kg
- Housing: animals were housed individually in suspended cages.
- Diet: 2930C Teklad Global Rodent diet (Harlan Laboratories UK Ltd., Oxon, UK), ad libitum
- Water: mains drinking water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23
- Humidity (%): 30-70
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 g (moistened with 0.5 mL distilled water to achieve a paste) - Duration of treatment / exposure:
- animal 1: 3 min, 1h and 4 h; animals 2 and 3: 4 h
- Observation period:
- 72 h
Reading time points: 1, 24, 48 and 72 h - Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm on the back of the rabbit
- Type of wrap if used: the test substance was placed on a cotton gauze patch, which was held in contact with a strip of surgical adhesive tape. The trunk of the animal was wrapped in an elastic corset during exposure.
REMOVAL OF TEST SUBSTANCE
- Washing: residual test substance was removed by gentle swabbing with cotton wool soaked in distilled water.
- Time after start of exposure: 3 min, 1 h and 4 h in animal 1; 4 h in animals 2 and 3
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: mean after 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: mean after 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: mean after 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: mean after 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Irritant / corrosive response data:
- No effects on skin irritation were observed in animal 1 3 min and 1 h after test substance application. In the same animal very slight erythema was noted at the treated site of skin immediately and 1 h after exposure to the test substance for 4 h. Very slight erythema was also observed in animal 3 at the 24 and 48 h readiong time points after 4 h treatment. In animal 2, no skin irritation effects were noted at any of the observation time points.
- Other effects:
- No further local or systemic effects were observed.
Any other information on results incl. tables
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD not classified - Executive summary:
The skin irritation potential of PF-6 was investigated in a study according to OECD guideline 404 and GLP. The test substance (0.5 g moistened with 0.5 mL distilled water) was applied to the clipped skin of 3 young adult New Zealand White (Hsdlf:NZW) rabbits under semiocclusive conditions. The first animal was exposed to the test substance for 3 min, 1 h or 4 h, whereas in the further 2 animals treatment was performed for 4 h. The scoring of skin reactions (erythema and edema) was performed 1, 24, 48 and 72 h after patch removal. Exposure to the test substance for 3 min or 1 h did not elicit any skin reactions at the application site of the first animal at any of the observation time points. In the same animal, very slight erythema was observed 1 h after exposure to the test substance for 4 h, which was reversible within 24 h. Very slight erythema was also observed in the third animal at the 24 and 48 h, but not at the 72 h reading time point after 4 h treatment. In the second animal, no skin irritation effects were noted at any of the observation time points. No signs of systemic toxicity were seen in any of the animals tested. The mean erythema and edema scores after 24, 48 and 72 h were 0 for the first and second animal. In the third animal, the mean erythema and edema scores after 24, 48 and 72 h were 0.67 and 0, respectively.
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