Registration Dossier
Registration Dossier
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EC number: 203-818-8 | CAS number: 110-95-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
TMPDA can be considered as toxic to algae.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 10 mg/L
- EC10 or NOEC for freshwater algae:
- 1.1 mg/L
Additional information
The determination of the growth inhibition of the fresh algae Pseudokirchneriella subcapitata exposed to Tetramethyltrimethylenediamine (TMPDA) for a duration of 72h was performed following the method OECD 201 and according to GLP (Gancet, 2003). Algae were exposed to the following nominal concentrations for 72h: 0, 0.5, 1.28, 2.8, 6.2, 13.6 and 30mg/L. Initial and final concentrations were equivalent to nominal concentrations. Therefore, calculations of effective concentrations EC50 and EC10 were performed using initial values.
The study was performed using an algal suspension so that the initial cell concentration was equal to 1x10E4 cells/mL. The algal concentration was measured daily. The validity criteria of the study were fulfilled. The ErC50_72h and ErC10_72h were determined to be 10 mg/L and 1.1 mg/L, respectively.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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