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Diss Factsheets
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EC number: 915-926-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974-05-06
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- female animals only, 10 animals per group
- GLP compliance:
- no
- Remarks:
- predates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N,N-dibutyloleamide and oleic acid, sulphated, sodium salts
- EC Number:
- 915-926-9
- Molecular formula:
- C18H34Na2O6S + C26H52NNaO5S
- IUPAC Name:
- N,N-dibutyloleamide and oleic acid, sulphated, sodium salts
- Test material form:
- liquid
- Details on test material:
- The water content of the actual test item was 57.6% (w/w); the water content of the REACH registration substance was analytically determined to be 3.8% (w/w).
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Humectol CX spezial
- Substance type: fatty acid derivative
- Physical state: liquid
- Analytical purity: no details
- Impurities (identity and concentrations): no data
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- 25 % solution
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25 % - Doses:
- 2500, 4000, 6300, 10000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation daily and weighing weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, - Statistics:
- no data
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 609 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 3 808 - <= 5 578
- Remarks on result:
- other: Probit analysis nach Linder & Weber; Vertrauensgrenzen nach Cavalli-Sforza
- Mortality:
- Animals died 2 hours to 2 days after treatment
Dose Mortality
2500 0/10
4000 5/10
6300 7/10
10000 10/10 - Clinical signs:
- other: Animals showed piloerection, red secretion from the nose and reduced general behaviour before death. Shortly before death tonic seizures were observed.
- Gross pathology:
- At necropsy reddish secretion was detected in the gut of deceased animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material is not classified due to an LD 50 value of > 2000 mg/kg body weight (4609 mg/kg bw).
- Executive summary:
Humectol CX special, which had the appearance of a red-brown oily liquid, was administered once as a 25 % solution in water in various doses by means of a stomach tube to female SPF Wistar rats. The test was carried out in female rats because no sex-related differences were observed in preliminary tests. For every dose, 10 rats were used. The animals’ feed was withdrawn 16 hours before application, and resumed 2 hours after application of the solution. Observation time after the application lasted 14 days. During this time, in which the animals were weighed once a week, the animals received as feed a diet of ALTROMIN 1324 from the firm of Altrogge in Lage/Lippe, Germany and mains water. Feed and water were made available at will. The animals were kept in plastic cages on wood shavings. The LD50 as determined by means of a probit analysis (method according to LINDER and WEBER) was 4609 mg test item/kg bw. The lethally poisoned animals showed bristled skin, bloody secretion from the nose and lethargic behavior. Death occurred with tetanic cramps.
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