Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-625-1 | CAS number: 123-41-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Flammability
Administrative data
Link to relevant study record(s)
- Endpoint:
- flammability, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-05-01 to 2008-06-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well-documented GLP-study.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The test item is transferred into a glass reaction vessel. The vessel is heated up to discrete temperature levels and the sample is agitated to allow thermal equilibrium and total vaporisation of the sample to occur. A high voltage (15kV) power supply is used to produce the continuous high-energy (spark) ignition source, observations are then made as to whether upward and outward flame propagation is observed.
- GLP compliance:
- yes
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Although no testing guideline is available, the test procedure is well-documented, compliant with GLP and meets general scientific requirements to assess the flammability of the test item. Therefore, the study was attributed a reliability 1 and so the results can be used to assess the physico-chemical hazards of the test item.
The sample is not considered to be a flammable liquid due to the results obtained for the flammable limits whereby no ignition could be obtained up to beyond the boiling point. - Executive summary:
The flammable limits for the test item were analyzed by observing the evaporized substance when exposed to a high-energy ignition source; no test guideline is available, but testing was performed compliant to GLP and the study is considered to be reliable. The flammable range could not be determined as the sample decomposed. The test item is not considered to be a flammable liquid.
Reference
Table 1: Results for Lower & Upper Flammable Limits
Vapour / air % (v/v) |
Sample Quantity (cm3) |
Temperature (°C) |
Barometric Pressure (kPa)
|
Comments |
0.2 |
0.10 |
75 |
101.3 |
Sample does not vaporise |
0.3 |
0.10 |
100 |
101.3 |
Sample does not vaporise - discolours |
0.3 |
0.10 |
100 |
101.3 |
Sample decomposes |
The flammable range could not be determined as the sample decomposed.
No explicit testing was performed; however, ignition in contact with air did not occur during testing procedure.
Description of key information
The substance is not considered to be a flammable liquid.
Although the pure substance is a solid, flammability testing and evaluation with respect to pyrophoricity, contact with water and self-heating was done with the aqueous solution according to CLP requirements. The substance is only handled and sold as liquid.
Key value for chemical safety assessment
- Flammability:
- non flammable
Additional information
The experimental results for flammability testing of Choline base derived in the Key Study were chosen because the study can be considered to be of reliability 1 due to its well-documented performance and compliance to GLP. So, no necessity for further testing is indicated and the existing results can be used to assess the physico-chemical hazards of the test item. The flammable range could not be determined as the sample decomposed.
Consequently, Choline base does not need to be classified as flammable and no physical hazard due to flammable properties can arise from the substance.
As supportive information data on self-heating and flammability for choline chloride is provided, as it is expected to have a similar flammability behaviour as pure choline hydroxide.
Justification for classification or non-classification
The substance is not considered to be a flammable liquid. The flammable range could not be determined as the sample decomposed.
Therefore, Choline hydroxide does not need to be classified as flammable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.