Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 403-030-6 | CAS number: 137398-54-0 ROBAC AS/100
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study was undertaken between 7 and 21 January 1986.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete or methodological deficiencies, which do not affect the quality of relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Di-isopropyl xanthogen polysulphide
- IUPAC Name:
- Di-isopropyl xanthogen polysulphide
- Details on test material:
- - Name of test material (as cited in study report): D.I.X.T (Di-isopropyl xanthogentetrasulphide [poly sulphide])
- Physical state: Clear yellow, oily liquid
- Storage condition of test material: ambient temperature in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Obtained from Froxfield Rabbits, Petersfield, Hampshire.
- Age at study initiation: Approximately 11 to 13 weeks of age.
- Weight at study initiation: Weight range 2.4 to 3.0 kg, prior to treatment on Day 1
- Housing: The rabbits were individually housed in metal cages with perforated floors
- Diet (e.g. ad libitum): Free access to SDS Standard Rabbit Diet.
- Water (e.g. ad libitum): Free access to tap water.
- Acclimation period: The rabbits selected for the study were all acclimated to the laboratory environment.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Room temperature was maintained at approximately 19°C.
- Humidity (%): Relative humidity at 30-70%.
- Air changes (per hr): Air exchange was maintained at approximately 19 air changes per hour.
- Photoperiod (hrs dark / hrs light): Lighting was controlled by means of a time switch to give 12 hours of artificial light (0700-1900 hours) in each 24 hour period.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): A 0.5 ml aliquot of D.I.X.T. was applied. - Duration of treatment / exposure:
- SIngle application for a four hour period.
- Observation period:
- Examination of the treated skin was made on Day 1 (i.e. approximately 30 minutes after removal of the patches) and on Days 2, 3 and 4. Additional observations were made on Days 5 through 14.
- Number of animals:
- 6
- Details on study design:
- TEST SITE
Approximately 24 hours prior to application of the test substance, hair was removed with electric clippers from the dorso-lumbar region of each rabbit exposing an area of skin approximately 10 cm square.
A 0.5 ml aliquot of D.I.X.T. was applied under a 2.5 cm square gauze pad to one intact skin site on each animal.
Each treatment site was occluded with "Elastoplast" elastic adhesive dressing for a four hour period. The animals were not restrained during the exposure period and were returned to their cages.
REMOVAL OF TEST SUBSTANCE
At the end of the exposure period, the semi-occlusive dressing and gauze pad were removed and the treatment site was washed using distilled water to remove any residual test substance.
SCORING SYSTEM:
Grading and scoring of the dermal reactions were performed using the prescribed numerical scoring system as follows:
Erythema and eschar formation:
No erythema: 0
Very slight erythema (barely perceptible): 1
Well-defined erythema: 2
Moderate to severe erythema: 3
Severe erythema (beet redness) to slight eschar formation (injuries in depth): 4
Oedema formation:
No oedema: 0
Very slight oedema (barely perceptible): 1
Slight oedema (edges of area well-defined by definite raising): 2
Moderate oedema (raised approximately 1 millimetre): 3
Severe oedema (raised more than 1 millimetre and extending beyond the area of exposure): 4
Any other lesion not covered by this scoring system, will be described.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- Mean of all animals (6 in total) scores for erythema
- Time point:
- 24/48/72 h
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- other: Erythema persisted up to day 14 in 4 animals. 2 animals showed no effects after 4 days.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- Mean of all animals (6 in total) scores for oedema
- Time point:
- 24/48/72 h
- Score:
- 1.1
- Max. score:
- 4
- Reversibility:
- other: Oedema persisted up to day 14 in 4 animals. 2 animals showed no effects after 4 days.
- Irritant / corrosive response data:
- The numerical scores awarded to the dermal reactions elicited by D.I.X.T. are given in Table 1.
Very slight erythema and oedema was observed in all six rabbits following removal of the bandages on Day 1. Very slight to well-defined erythema with or without very slight oedema was seen in all six rabbits on Day 2. These reactions ameliorated in two animals and had resolved completely by Day 4 in these animals.
Well-defined erythema with slight to moderate oedema developed in the four remaining animals.
Well-defined dermal reactions persisted in four animals at Day 14.
Desquamation of the stratum corneum was seen in three animals.
Any other information on results incl. tables
Table 1: Dermal reaction elicited by DIXT
Rabbit Number (male) |
E= Erythema O – Oedema |
Day |
|||||||||||||
1* |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
||
1101 |
E O |
1 1 |
1 1 |
2 1 |
2 2 |
2 2 |
2 2 |
2A 2 |
2A 2 |
2 2 |
2 2 |
1 2 |
1 2 |
1 2 |
1 2 |
1102 |
E O |
1 1 |
2 1 |
2 2 |
2 2 |
2 2 |
2 2 |
2A 2 |
2A 2 |
2 2 |
2 1 |
2 2 |
2 2 |
1 2 |
1 2 |
1103 |
E O |
1 1 |
2 1 |
1 1 |
0 0 |
|
|
|
|
|
|
|
|
|
|
1104 |
E O |
1 1 |
1 1 |
2 1 |
2 2 |
2 2 |
2 2 |
1 2 |
1 2 |
1 2 |
1 1 |
1 2 |
2 2 |
2 2 |
2 2 |
1105 |
E O |
1 1 |
1 0 |
1 0 |
0 0 |
|
|
|
|
|
|
|
|
|
|
1106 |
E O |
1 1 |
1 1 |
2 2 |
2 2 |
2 2 |
2 2 |
2A 3 |
2 3 |
2 3 |
2 3 |
2 2 |
2 2 |
2 2 |
2 2 |
* Approximately 30 minutes after removal of the dressing
A: Desquamation of the stratum corneum.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A single semi-occlusive application of D.I.X.T. to intact rabbit skin for four hours elicited well-defined to moderate dermal irritation.
- Executive summary:
Introduction:
The experimental procedure used followed the Testing Guidelines as described in the Federal Register, Vol. 50, No. 188, Part 11 of 27 September 1985, Section 798.4470 - Primary Dermal Irritation.
Results:
A single 4-hour, semi-occluded application of the test item to the intact skin of 6 New Zealand White strain rabbits produced the following results:
Very slight erythema and oedema was observed in all six rabbits following removal of the bandages on Day 1. Very slight to well-defined erythema with or without very slight oedema was seen in all six rabbits on Day 2. These reactions ameliorated in two animals and had resolved completely by Day 4 in these animals.
Well-defined erythema with slight to moderate oedema developed in the four remaining animals.
Well-defined dermal reactions persisted in four animals at Day 14.
Desquamation of the stratum corneum was seen in three animals.
Conclusion:
A single semi-occlusive application of D.I.X.T. to intact rabbit skin for four hours elicited well-defined to moderate dermal irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.