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Diss Factsheets
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EC number: 444-900-5 | CAS number: 49667-22-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
The following ecotoxicological data are available
Daphnia magna (invertebrate) (Tobor-Kaplon, 2016a)
· 48h-EC50 of 60 mg/L (95%CL: 54-79 mg/L)
Pseudokirchneriella subcapitata (green alga) (Tobor-Kaplon, 2016b)
· 72h-ErC50: >100 mg/L
· 72h-NOECr: 32 mg/L
Effects levels based on biomass are a 72h-EbC50 of 449 mg/L and a 72h-NOECb of 10 mg/L.
The ECHA Guidance on the application of CLP criteria states that for algae, “Classification shall be based on both the algal growth rate reduction endpoints (ErC50 and NOErC) provided that the control growth is exponential. This endpoint is preferred because it is not dependent on the test design, whereas the endpoint, biomass (growth) inhibition (EbC50) depends on both, growth rate of the test species as well as test duration and other elements of test design”.
Acute classification under CLP: based on the lowest EC50.
Daphnia magna is the most sensitive species (ERVacute: 60 mg/L). Based on this value, the substance is not classified for the Aq.Acute enpoint.
Chronic classification under CLP:
Chronic data are missing for some trophic levels; (no data for fish and forD.magna(most sensitive taxonomic group). According to the 2nd ATP of the CLP (2011), chronic classification needs to be determined in two ways, and the most stringent classification has to be used
a) based on chronic data
b) surrogate method (based on acute data).
Using the only available chronic value of 32 mg/L, the substance is not classified for the Aq.Acute enpoint.
Using the surrogate method, the ERVacute of 60 mg/L results in an Aq. Chronic Cat.3 classification.
Conclusion:
The substance is not classified for the acute environmental endpoint
The substance is classified as Aq.Chronic Cat.3
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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