Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 404-740-9 | CAS number: 115895-09-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
DT50 pH 4 (25 °C) = 26 hours
DT50 pH 7 (25 °C) = 219 hours
DT50 (25 °C) = 1147 hours
Key value for chemical safety assessment
Additional information
The abiotic degradation of ethyl 3,5 -dichloro-4 -hexadecyloxybenzoate (AF-366) via hydrolysis was investigated by Rhemrev-Boom (1989) and Rhemrev-Boom and Houtzager (1992). The first study was a preliminary test conducted according to OECD 111 under GLP conditions. The test substance was incubated for 5 days at 50 °C in three different buffered solutions, at pH 4, pH 7 and pH 9. The results of the test showed that > 10% hydrolysis took place in all three solutions (30% at pH 4, 39% at pH 7 and 49% at pH 9) and therefore, further testing was needed in order to determine the precise abiotic degradation of the substance.
The second (main) test was performed according to the Council Directive 67/548/EEC method “Hydrolysis as a function of pH”. A preliminary study was carried out for 44 hours, after which it was deemed necessary to continue with the full test. The test substance was incubated at pH 4, 7 and 9 at two different temperatures (25 °C and 50 °C). The entire test was conducted under sterile conditions and the temperature controlled within 0.5 °C of the nominal temperatures. Under environmentally relevant conditions (25 °C) the half-lives of the substance were 26 hours, 219 hours and 1147 hours at pH 4, pH 7 and pH 9, respectively.
These values indicate that ethyl 3,5 -dichloro-4 -hexadecyloxycarbonyloxybenzoate (AF-366)
can be expected to be rapidly degraded abiotically in water at pH 4 and pH 7, but is considered to be hydrolytically stable at pH 9.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.