Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 602-890-1 | CAS number: 122731-58-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-03-20 to 2002-03-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- rac-N-(2,3-Dihydroxypropyl)-5-nitroisophthalamic acid
- EC Number:
- 602-890-1
- Cas Number:
- 122731-58-2
- Molecular formula:
- C11 H12 N2 O7
- IUPAC Name:
- rac-N-(2,3-Dihydroxypropyl)-5-nitroisophthalamic acid
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- Three test solutions, buffered to pH values of 4, 7 and 9, each with a ZK 39166 concentration of approx. 10 mg/L, were prepared by adding a stock solution of ZK 39166 in acetonitrile to the corresponding buffer solution which had been equilibrated at 50 °C for one hour followed by purging with nitrogen to remove dissolved oxygen. All experiments were conducted using sterilized equipment and buffer solutions.
- Buffers:
- -0.05 M acetate buffer solution pH 4
0.657 g =0.008 mol sodium acetate p.a. Merck Art. 106268 (M = 82.03 g/mol) and
2.4 mL =0.042 mol acetic acid 100 % p.a. Merck Art. 100063 E (M = 60.05 g/mol, density = 1.05 g/mL
were dissolved to 1000 mL with double distilled water. The pH value was adjusted to 4 by adding acetic acid (see above).
-0.05 M phosphate buffer solution pH 7
4.34 g=0.031 mol disodium hydrogen phosphate Merck Art. 106566 (M = 141.96 g/mol) and
2.64 g = 0.019 mol potassium dihydrogen phosphate Merck Art. 105108 (M = 136.09 g/mol) were dissolved to 1000 mL with double distilled water. The pH value was adjusted to by adding 0.1 M sodium hydroxide solution (Titrisol Merck Art. 109959)
-0.05 M borate buffer solution pH 9
2.52 g=0.0125 mol disodium tetraborate Merck Art. 106309 (M = 201.22 g/mol) and 46 mL=0.0046 mol hydrochloric acid Titrisol Merck Art. 109973 (0.1 M) were dissolved to 1000 mL with double distilled water. The pH value was adjusted to 9.20 by adding 0.1 M sodium hydroxide solution (Titrisol Merck Art. 109959) in order to take into account the temperature dependence of the pH of this buffer solution 2).
Duration of testopen allclose all
- Duration:
- 119.2 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 10.15 mg/L
- Duration:
- 118.9 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 10.18 mg/L
- Duration:
- 119.8 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 10.22 mg/L
- Number of replicates:
- 3 per pH
Results and discussion
- Transformation products:
- no
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 9
- Temp.:
- 50
- DT50:
- > 1 yr
- Key result
- pH:
- 7
- Temp.:
- 50
- DT50:
- > 1 yr
- pH:
- 4
- Temp.:
- 50
- DT50:
- > 1 yr
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
No hydrolytic degradation occured within five days at pH 4, 7 and 9 at 50 ± 0.1 °C. According to the EC test guideline, ZK 39166 can therefore be considered hydrolytically stable at pH 4, 7 and 9 (DT50 > 1 year at 25 °C).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.