Registration Dossier
Registration Dossier
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EC number: 604-759-4 | CAS number: 150928-21-5
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- rac-3-(2,3-Diacetoxypropylcarbamoyl)-2,4,6-triiodo-5-methoxyacetylaminobenzoyl chloride
- EC Number:
- 604-759-4
- Cas Number:
- 150928-21-5
- Molecular formula:
- C18 H18 Cl I3 N2 O8
- IUPAC Name:
- rac-3-(2,3-Diacetoxypropylcarbamoyl)-2,4,6-triiodo-5-methoxyacetylaminobenzoyl chloride
Constituent 1
Results and discussion
Dissociation constant
- No.:
- #1
- pKa:
- <= 10.2
Applicant's summary and conclusion
- Conclusions:
- The pKa-values obtained in aqueous solution at different wavelength are given in Table 1. Tab. 1: Apparent pKa-values at wavelengths used for determination
λ (nm) pKa
240 9.74
310 10.71
Averaging the results obtained at the two wavelengths the following mean pKa value was obtained: pKa = 10.2 - Executive summary:
The acid dissociation constant of ZK 91445 was determined at 23 °C with a modified photometric method at different wavelengths to be: pKa = 10.2
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