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EC number: 601-093-6 | CAS number: 111453-32-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 202, part b
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- rac-5-Amino-N-(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamic acid
- EC Number:
- 601-093-6
- Cas Number:
- 111453-32-8
- Molecular formula:
- C11 H11 I3 N2 O5
- IUPAC Name:
- rac-5-Amino-N-(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamic acid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 2222 mg (start of experiment) and 2000 mg (further preparations), respectively, of ZK 39.211 were suspended in approximately 1600 ml tap water. This mixture was adjusted to approximately pH 7 by addition of 1 N NaOH. The mixture was filled up to 2000 mL with tap water. From this solution 30, 100, and 300 mL, respectively, were filled up to 1000 mL with tap water. All solutions were prepared freshly before each change of test solution.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain/clone: Schering AG
- Age at study initiation (mean and range, SD): 0-24 h
ACCLIMATION
- Acclimation conditions (same as test or not): same as test
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
Test conditions
- Test temperature:
- 18.9-21.8 °C
- pH:
- 7.7 - 8.7
- Dissolved oxygen:
- 8.2 - 11.8 mg/L
- Nominal and measured concentrations:
- nominal: control, 30, 100, 300, 1000 mg/L
- Details on test conditions:
- TEST SYSTEM
10 Daphnia were used for the test and for the control solutions, randomly distributed individually into the test vessels. Labelled 100 ml test vessels were used and filled with 80 ml of the test solutions and the dilution water (control group). One additional test vessel for the test concentrations and the control was used without Daphnia for the measurements of pH, temperature and oxygen content. The test started when the animals were added to the previously prepared test solution. The Daphnia were exposed to the test concentration and the control for a period of 22 days under semi-static conditions, i.e. the test and control solutions were changed three times per week. The light/dark rhythm was adjusted to 12 hours/12 hours. - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 300 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- immobilisation
Any other information on results incl. tables
The quality criteria for the control noted in the draft DIN guideline (3) regarding number of offspring per parent animal (> 60), mortality < 10%) and the recommended variability between animals for the number offspring compared to the mean < 25%) are met. The highest concentration showed slightly higher variability as the other groups. There is no inhibitory effect of ZK 39.211 on the reproductivity of Daphnia magna at the concentrations studied. The observed mortality at 30 and 300 mg/L is probably of spontaneous nature. However, the mortality of 30% in the highest concentration exceeds the range 'recommended in the guideline for the control group. Therefore, regarding mortality, the NOEC is 300 mg/L and the LOEC is 1000 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The NOEC for chronic exposure of Daphnia magna to Tamip monoamid (ZK 39.211) over 21 days was > 1000 mg/L (reproduction) and 300 mg/L (mortality).
- Executive summary:
Ten daphids were used for each of the 4 test concentrations and 10 for the control group. The daphnids were exposed to the test compound (30 -1000 mg/L) over 21 days. The test solution was changed 3 times per week.
The measured concentrations were always >90% of the nominal. Mean number of off-spring varied between 95 (control group) and 137 (second highest concentration), which was not substance related. Survival of parent animals was 9 -10 at all concentrations including the controls, except at the highest concentration, where it was only 7. Therefore, the NOEC for mortality was 300 mg/L, the LOEC was 1000 mg/L. For reproduction the NOEC was > 1000 mg/L.
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