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EC number: 406-850-2 | CAS number: 133855-98-8 BAS 480 F
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in soil
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Half-life in soil:
- 189 d
- at the temperature of:
- 20 °C
Additional information
Parent compound:
Experimental data are available for the assessment of the aerobic and anaerobic degradation of epoxiconazole in soil. Studies on the route of degradation of the test substance in soil conditions were performed with oxirane and fluorophenyl labeled test compound.
In the GLP study with oxirane labelled test substance metabolism in soil was investigated in two soils (clay loam and sand). The test was conducted according to EPA 162-1 Guideline under dark conditions at 20 °C for up to 336 days. At the end of the study 34 and 67% TAR were recovered as parent. Two minor unidentified components were detected at levels < 4% TAR. Non-extractable residues accounted for 15.1 to 23.2% TAR at the end of the test procedure (Baranowski, rep. no.: 093014, 1989).
The degradation kinetics were re-evaluated using the experimental data given in the study and analyzing the kinetic parameters according to the current FOCUS guidance. The SFO kinetic model resulted in the best fit for this study. The half-life DegT50 was calculated to be 390.1 days for the clay loam soil and 173.2 days for the sand soil (at 20 °C, Voss, 2016).
Additionally, one study on the anaerobic degradation of epoxiconazole is available. This GLP study was conducted according to german BBA Guideline IV 4-1. The study was investigated at 20 °C for 120 days with the fluorophenyl labelled test compound in a loamy sand soil. At the end of the study, 55% TAR were recovered as parent. Non-extractable residues accounted for 24.2% TAR at the end of the study (BASF AG, rep.no.: 58246, 2003). In both studies the biggest amount of the non-extractable residues was assigned to the humin fraction.
The degradation kinetics were re-evaluated using the experimental data given in the study and analyzing the kinetic parameters according to the current FOCUS guidance. The DFOP model resulted in the best fit for this study. The half-life DegT50 was calculated to be 187.8 days for the loamy sand soil (at 20 °C, Sachers, 2016).
Metabolites
Regarding the metabolism of epoxiconazole under aerobic conditions, it can be concluded that during metabolism of the test substance (oxirane labeled) in soil, no metabolites appeared in major amounts. Only very small amounts unknown metabolites appeared (max 4 % TAR). According to the TLC analytics the analyzed fraction with unknown metabolites could be separated into at least four further fractions of which two spots migrated similar to the reference compound BF 480-11. For further characterization, isolated fractions and BF 480-11 were tried to derivatize with diazomethane. After the methylation procedure, the moieties were analysed again by TLC. These additional investigations demonstrated that - if at all - only very trace amounts could be contributed to BF 480-11 in the soil extracts.
The concentration of the non-extractable residues amounted up to about 20% TAR. The residual fraction after alkaline extraction was the humin fraction, the fraction soluble after acidification was the fulvic acid fraction and that soluble in alkaline but insoluble in acidic solution the humic acid fraction (for details see the Table 1 below).
Table 1. Characterization of non-extractable residues (% TAR)
|
Clay/clay loam |
Sand |
Fulvic acid |
2.3 |
5.1 |
Humic acid |
2.2 |
5.4 |
Humin |
18.7 |
9.5 |
The results show that the most portion of radioactivity was bound to the humin fraction. This makes it very likely that there is no concern to be expected with regard to release of active substance from the bound residues, because the number of bound residues is low and because they are tightly incorporated onto the humins being insoluble.
Two metabolites were identified for the parent compound as relevant degradation products under anaerobic test conditions in terms of PBT/vPvB assessment, with an estimated quantity of ≥ 0.1%. The metabolite BF 480-entriazole was identified with a maximum amount of 8.6% TAR after 120 days. The second metabolite BF 480-Alcohol remained constant at 1.2% TAR during the test procedure. From the pattern of identified metabolites, it is concluded that the first step in the degradation of the parent compound in anaerobic conditions consists of a cleavage of the oxirane ring, resulting in the formation of the alcohol BF 480-alchol which is readily dehydrated to the alkene BF 480-entriazol. Further outcomes are the formation of bound residues and to a minor extent the formation of CO2. However, for the metabolite BF 480-entriazol, no reliable degradation endpoints could be derived as no acceptable fit was obtained.
The concentration of the non-extractable residues amounted up to about 20% TAR. The residual fraction after alkaline extraction was the humin fraction, the fraction soluble after acidification was the fulvic acid fraction and that soluble in alkaline but insoluble in acidic solution the humic acid fraction (for details see the Table 2 below).
Table 2. Characterization of non-extractable residues, anaerobic conditions (% TAR)
Duration (d) |
NaOH extract |
Humin |
14 |
2.0 |
7.0 |
29 |
3.3 |
8.6 |
63 |
3.7 |
11.5 |
91 |
3.7 |
13.5 |
120 |
3.7 |
14.8 |
The results show that the most portion of radioactivity remained unextractable and was assigned to the humin fraction.
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