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EC number: 695-619-1 | CAS number: 623-72-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Remarks:
- Microbial degradation test (ready) of Ethyl 3-hydroxypropanoate
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2022.03.08 ~ 2022-05-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- OECD guidelines for the testing of chemicals 301 C “MODIFIED MITI TEST(I)” (Adopted : 17 July 1992)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- ethyl 3-hydroxypropanoate
- Cas Number:
- 623-72-3
- Molecular formula:
- C5H10O3
- IUPAC Name:
- ethyl 3-hydroxypropanoate
- Test material form:
- liquid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- mixture of sewage, soil and natural water
- Remarks:
- Cultured samples which is selected and taken water from ten sites such as river, lake, sewage treatment work and industrial waste-water treatment work in February, May, August and November (four times a year) were used in the test and the collected.
- Details on inoculum:
- Inoculum samples which were collected from various sites were mixed and then they were filtered through filter paper after removing floating matter. Filtered supernatant was put into 2 L glass bottle, moved into the incubation chamber and provided oxygen for about 23.5 hours. After that, they were stopped to provide oxygen for thirty minutes. One-third of the whole volume supernatant was removed and the supernatant was provided oxygen again after the equal volume of a solution containing 0.1 % each of glucose, peptone and potassium orthophosphate was put into 2 L glass bottle. After checking that more than of 107 cells/mL lived in Nutrient Agar medium, the cultured inoculum was used in the test.
- Duration of test (contact time):
- ca. 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- ca. 100 mg/L
- Based on:
- not specified
- Initial conc.:
- ca. 162.53 other: mg O2/L
- Based on:
- ThOD
- Details on study design:
- # Incubation of Inoculum
- Incubation room : Biodegradability test room
- Incubator : HB-103M, Hanbaek scientific technology, Korea
- Temperature : (23 - 27)℃
- Vessel : 2 L glass bottle
- Photoperiod : Dark condition
- pH : 7 ± 1
- Dissolved oxygen : >5 mg/L
- Culture medium : 0.1 % each of glucose, peptone and potassium orthophosphate
- {mixture (inoculum) was adjusted to pH 7 ± 1 with sodium hydroxide}
- Medium renewal : Every 24 h
# Test room : Biodegradability test room
- Incubator : HB-103M, Hanbaek scientific technology, Korea
- BOD meter : Automatic recording BOD meter with stirring (OxiTopⓇ-C)
- Inoculum : Cultured inoculum for more than 1 month
- Temperature : (24 - 26) ℃
- Test period : 28 day
- Light : Dark condition
Reference substance
- Reference substance:
- other: Sodium benzoate
Results and discussion
% Degradationopen allclose all
- Key result
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- Based on these results, the percentage degradation of test substance [Ethyl 3-hydroxypropanoate] by BOD meter were 81.3, 77.6 and 81.3 % (mean : 80.0 %), respectively.
- Value:
- ca. 77.6 - 81.3
- St. dev.:
- 2.1
- Sampling time:
- 28 d
- Parameter:
- % degradation (test mat. analysis)
- Remarks:
- A result of the analysis after 28 days, abiotic control and test substance treatment group were 93.3, 0.0, 0.0 and 0.0 mg/L, respectively. Based on these results, the percentage degradation of test substance by analysis were 100.0 %.
- Value:
- ca. 100
- Sampling time:
- 28 d
- Details on results:
- It is considered that there will be ready biodegradation by microorganism in aquatic environment in that the degradation percentage measured by BOD meter was more than 60 % according to the OECD guidelines.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- The test substance could be concluded to be readily degradable by microorganism in the aquatic environment based on the OECD pass level of biodegradability (60 %).
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The microbial degradation rate of the reference substance, sodium benzoate, was met OECD specification which the microbial degradation rate was more than 40 % after 7 days and more than 65 % after 14 days. Therefore, the activity of the inoculum used in the test was suit.
The BOD value (0 - 16.9 mg O2/L) of the inoculum blank used in the microbial degradation test for 28 days was suit for the OECD specification (less than 60 mg O2/L).
The pH range (test bottle 2, 3, 4, 6) was suit for 6.0-8.5.
The temperature of the incubator was suit for OECD specification which its range is 24 ℃ - 26 ℃.
The deviation of the microbial degradation rate of the test bottle 2, 3 and 4 was suit for OECD specification (less than 20 %)
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