Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 856-079-4 | CAS number: 55860-35-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 03 January 2013 to 10 January 2013
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
- Principles of method if other than guideline:
- A group of three fasted female rats was treated with the substance by oral gavage at a dose level of 300 mg/kg bw. Dosing was performed sequentially. The test substance was administered as a solution in 1% carboxymethyl cellulose. Clinical signs and bodyweight development were monitored during the study. All animals were subjected to gross necropsy.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-acetyl-2-methylbenzoic acid
- EC Number:
- 856-079-4
- Cas Number:
- 55860-35-0
- Molecular formula:
- C10H10O3
- IUPAC Name:
- 4-acetyl-2-methylbenzoic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- No details reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- Test substance was administered as a solution in 1% carboxymethyl cellulose
- Doses:
- 300 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- A group of three fasted female rats was treated with the test item at a dose level of 300 mg/kg bodyweight. Dosing was performed sequentially. The test item was administered orally as a solution in 1% carboxymethyl cellulose. Clinical signs and bodyweight development were monitored during the study over a period of 7 days. All animals were subjected to gross necropsy.
- Statistics:
- Not applied
Results and discussion
- Preliminary study:
- The oral LD50 value in female Wistar rats was estimated to be >300 mg/kg bw.
- Mortality:
- No mortality occurred.
- Gross pathology:
- No abnormalities detected
Any other information on results incl. tables
Development of bodyweight of test animals
Dose (mg/kg bw) | Animal number | Bodyweight (g), Day -1 | Bodyweight (g), Day 0 | Bodyweight (g), Day 7 | Bodyweight gain (g) |
300 | 1-0 | 194 | 189 | 201 | 12 |
300 | 1-1 | 177 | 174 | 195 | 21 |
300 | 1-2 | 189 | 184 | 199 | 15 |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The oral LD50 of the substance in female Wistar rats was estimated to be >300 mg/kg bw.
- Executive summary:
In a preliminary acute oral toxicity test, a group of three fasted female Wistar rats was treated by oral gavage with the test item at a dose level of 300 mg/kg bodyweight. Dosing was performed sequentially. The test item was administered orally as a solution in 1% carboxymethyl cellulose. Clinical signs and bodyweight development were monitored during the study over a period of seven days. All animals were subjected to gross necropsy. No mortality or adverse effects were observed and no abnormalities were noted at necropsy.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.