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EC number: 953-797-0 | CAS number: 210300-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 (Bioaccumulation in Fish: Aqueous and Dietary Exposure) -I: Aqueous Exposure Bioconcentration Fish Test
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-hydroxy-4-methoxypyridine-2-carboxylic acid
- Cas Number:
- 210300-09-7
- Molecular formula:
- C7H7NO4
- IUPAC Name:
- 3-hydroxy-4-methoxypyridine-2-carboxylic acid
Constituent 1
- Specific details on test material used for the study:
- Substance ID: X696476
Lot #: YH1-143590-18-3
Purity: 100%
Radiolabeled substance
Substance ID: 14C-X12335145
Lot #: YH2-144026-008-MW
Radiochemical purity: 100%
Specific activity: 30.0 µCi/mmol - Radiolabelling:
- yes
Test solutions
- Vehicle:
- yes
- Remarks:
- Dilution water
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
Study design
- Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- other: laboratory freshwater
- Total exposure / uptake duration:
- 14 d
- Total depuration duration:
- 14 d
Test conditions
- Hardness:
- 140 to 154 mg CaCO3/L
- Test temperature:
- 22.7 to 23.5°C
- pH:
- 8.32 to 8.46
- Dissolved oxygen:
- 7.81 to 8.51 mg/L
- Conductivity:
- 331 to 342 μS/cm
- Nominal and measured concentrations:
- Nominal Concentrations: 0 (control) and 0.10 mg a.i./L
Results and discussion
Lipid contentopen allclose all
- Lipid content:
- 10.1 %
- Time point:
- other: overall
- Lipid content:
- 9.53 %
- Time point:
- end of exposure
Bioaccumulation factoropen allclose all
- Key result
- Conc. / dose:
- 0.102 mg/L
- Temp.:
- >= 22.7 - <= 23.5 °C
- pH:
- 8.32
- Type:
- BCF
- Value:
- 1.8 L/kg
- Basis:
- other: whole fish
- Calculation basis:
- other: steady state and kinetic
- Key result
- Conc. / dose:
- 0.102 mg/L
- Temp.:
- >= 22.7 - <= 23.5 °C
- pH:
- 8.32
- Type:
- BCF
- Value:
- 0.89 L/kg
- Basis:
- other: whole fish
- Calculation basis:
- other: 5% Lipid corrected, Steady State and Kinetic
Depuration
- Key result
- Parameter:
- other: Time to 95% Depuration
- Depuration time (DT):
- 25 d
Rate constantsopen allclose all
- Rate constant:
- other: uptake rate constant (L/kg/day)
- Value:
- 0.214
- Rate constant:
- other: depuration rate constant (day-1)
- Value:
- 0.12
Applicant's summary and conclusion
- Conclusions:
- Time to Steady State: 14 days
Time to 95% Depuration: 25 days
Steady State BCFss: 1.8 L/kg
TRR Kinetic BCFk: 1.8 L/kg
5% Lipid corrected, Steady State BCFssl: 0.89 L/kg
5% Lipid corrected, Kinetic BCFkl: 0.89 L/kg - Executive summary:
The bioconcentration potential of the test substance was evaluated by zebrafish, Danio rerio, exposed to one concentration of carbon-14 labeled test substance based on the OECD Guideline 305, Bioconcentration in Fish: Aqueous and Dietary Exposure.
Zebrafish, Danio rerio, were exposed to the test substance under flow-through conditions at one mean measured concentration, 0.102 mg TRR/L.
Steady state equilibrium tissue residues in whole fish were determined to be approximately 0.18 mg/kg, yielding an approximate steady state BCFss of 1.8 L/kg. Based on the ratio of the uptake and depuration rate constants (k1 = 0.2140 L/kg/day, and k2 = 0.1198 per day, respectively) the whole fish BCFk was calculated to be 1.8. Correction of the BCF values to a 5% lipid content yielded estimates of the BCFssl = 0.89 L/kg and the BCFkl = 0.89 L/kg.
Following transfer to clean water the whole body 14C-residue was rapidly depurated, with the calculated time to 95% depuration of the 14C-residue being 25 days. Radioactive residues extracted from the fish tissues did not match the retention time of the parent, indicating that the extracted residues were not the parent compound.
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