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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 JUL 2021 - 28 SEP 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- adopted July 27, 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- EC Publication No. O.J. L81, 19 March 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- Solubility: Column Elution Method; Shake Flask Method”
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Water solubility:
- < 0.05 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 7 - <= 7.3
- Conclusions:
- In conclusion the water solubility of tes item was determined to be under the LOQ (0.05 mg/L) at 20 ± 0.5 °C and pH 7.0–7.3, using the column elution method.
- Executive summary:
Applying the column elution method in a GLP-study according to OECD guideline 105, EU method A.6 and OPPTS 830.7840 the water solubility of the sample was determined to be under the LOQ of the method (0.05 mg/L) at 20 ± 0.5 °C and pH 7.0–7.3.
Reference
Calibration
Calibration solutions were prepared in 0.05 – 5 μg/mL concentration range and they were analysed by HPLC with three replicate injections from each. The calibration graph was calculated applying weighted linear regression. Weighting factor was 1/concentration. The data of the calibration lines are presented in the table below.
Table. Parameters of the calibration equations
Analytical occasion | Equation | r2 |
August 15, 2021 | f(x)=63527.3*x+419.602 | 0.999 |
August 16, 2021 | f(x)=67487.3*x+217.088 | 1.000 |
August 17, 2021 | f(x)=72198.5*x+408.930 | 0.998 |
August 24, 2021 | f(x)=68949.0*x+230.461 | 0.999 |
August 25, 2021 | f(x)=68742.2*x+182.929 | 0.999 |
August 26, 2021 | f(x)=65956.1*x+334.941 | 0.999 |
Measured Water Solubility
25 mL/h: samples were taken after 1, 2 and 3 days. The measured concentrations were under the LOQ (0.05 mg/L) after three days, the study was interrupted. Presence of the test item was verified by rinsing the micro-columns with tetrahydrofuran and subsequent HPLC measurement of the obtained solution.
12.5 mL/h: samples were taken after 1, 2 and 3 days. The measured concentrations were under the LOQ (0.05 mg/L) after three days, the study was interrupted. Presence of the test item was verified by rinsing the micro-columns with tetrahydrofuran and subsequent HPLC measurement of the obtained solution.
Measured pH values
Before the pH measurement, 2-point calibration of the pH meter was performed. The calibrated range was between 7–10, the measurement was performed at 20 ± 1 °C. The measured pH values were between 7.0 and 7.3.
Description of key information
Applying the column elution method in a GLP-study according to OECD guideline 105, EU method A.6 and OPPTS 830.7840 the water solubility of the sample was determined to be under the LOQ of the method (0.05 mg/L) at 20 ± 0.5 °C and pH 7.0–7.3.
Key value for chemical safety assessment
- Water solubility:
- 0.05 mg/L
- at the temperature of:
- 20 °C
Additional information
Key value for the chemical safety assessment is a limit-value because the real water solubility could not be observed with the available method. So the water solubility is below 0.5 mg/L which is the LOQ of the method.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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