2,4-xylenol

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1955

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

no guideline available

Principles of method if other than guideline:

The water solubility of the test substance was determined using the flask method. The test substance was dissolved in distilled water containing 0.8 g/L of potassium dihydrogen phosphate so that the buffering capacity was the same as in the culture solution for L. minor. Excess of the test substance was shaken up with about 100 or 200 mL. of the solvent in a bottle with a ground-glass stopper, and the bottle was then placed in a thermostat at 25°C. Each bottle was shaken periodically, and after 2 days the pH was adjusted to 5.1. This adjustment was repeated until the pH remained constant-usually after about a week-but the bottles with further shaking were left for at least an additional fortnight to ensure that the solutions were completely saturated. The the concentration of the test substance was determined by a suitable analytical method

GLP compliance:

not specified

Type of method:

flask method

Key result

Water solubility:

8 790 mg/L

Temp.:

25 °C

pH:

5.1

Conclusions:

Under the study conditions, the water solubility of the test substance was determined to be 8790 mg/L at 25°C

Executive summary:

A study was conducted to determine the water solubility of the test substance using the flask method. Under the study conditions, the water solubility of the test substance was determined to be 8790 mg/L at 25°C (Blackman, 1955).

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

no guideline available

Principles of method if other than guideline:

An excess of the test substance was added to a tube containing distilled water, and the tube was sealed and allowed to equilibriate at 25 ±0.2 degree C with constant or intermittent shaking. The solubility of test substance were analysed by using liquid scintillation counting (LSC)

GLP compliance:

not specified

Type of method:

flask method

Key result

Water solubility:

7 870 mg/L

Temp.:

25 °C

Remarks on result:

other: High water solubility

Conclusions:

Under the study conditions, the water solubility of the test substance was determined to be 7870 mg/L at 25°C

Executive summary:

A study was conducted to determine the water solubility of the test substance using the flask method. An excess of the test substance was added to a tube containing distilled water, and the tube was sealed and allowed to equilibriate at 25 ±0.2 degree C with constant or intermittent shaking. The solubility of test substance were analysed by using liquid scintillation counting (LSC). The entire procedure was carried out at least twice for each test substance, and each analysis was also conducted in duplicate. Under the study conditions, the water solubility of the test substance was determined to be 7870 mg/L at 25°C ( Banerjee, 1955).

Description of key information

The water solubility of the test substance was determined using the flask methods (Blackman, 1955; Baerjee, 1980).

Key value for chemical safety assessment

Water solubility:

8 790 g/L

at the temperature of:

25 °C

Additional information

The water solubility values of the test substance were determined to range from 7870 to 8790 mg/L at 25°C. The higher water solubility value which would maximise the exposure to environmental compartments has been considered further for hazard/risk assessment as a conservative approach.