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Diss Factsheets
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EC number: 208-761-2 | CAS number: 540-92-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- A routine inspection by FDA at Industrial Bio-Test laboratories (IBT) in 1976 uncovered numerous discrepancies between raw data and study reports, and gross deficiencies in study conduct; mainly in non-acute studies, but also in acute toxicity studies. Thus, study reports from IBT between the 1960´s and until 1978 should be taken with care. An important consideration is the consistency of the findings from the IBT study with findings from other studies that were conducted at reputable test houses at a later date to the IBT study (to rule out the possibility of data being manipulated by IBT to be consistent with existing data). REFERENCE: OECD (2005): Manual for investigation of HPV Chemicals, Chapter 3: Data Evaluation (3.1 Guidance for Determining the Quality of Data fo the SIDS Dossiers: Reliability, relevance and adequacy, 3.1.8 Acceptance and use of studies from Industrial Bio-Test laboratories. OECD - Manual for the Assessment of Chemicals (http://www.oecd.org/chemicalsafety/risk-assessment/chapter3dataevaluation.htm)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Draize- Test. Purity of the test material was not listed.
- GLP compliance:
- not specified
- Test type:
- other:
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium 2-hydroxypropane-2-sulphonate
- EC Number:
- 208-761-2
- EC Name:
- Sodium 2-hydroxypropane-2-sulphonate
- Cas Number:
- 540-92-1
- Molecular formula:
- C3H8O4S.Na
- IUPAC Name:
- sodium 2-hydroxypropane-2-sulphonate
- Test material form:
- solid
- Details on test material:
- white powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Pel.Freez, Inc. Arkansas, USA
- Age at study initiation: approx. 10-13 weeks
- Weight at study initiation: male (2.68 - 2.70 kg); femlae (2.78 - 3.12 kg)
- Housing: wire-bottomed steel cages
- Diet (e.g. ad libitum): ad libitum (Purina Rabbit Chow Checkers, Ralson Rurina Company, USA)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- Twenty-four hours prior to the dermal applications, the backs of the rabbits were clipped free of hair with electric clippers. The clipped area on each animal constituted about 30 percent of the total body surface area.
At the end of the 24-hour recovery period, just prior to the application of the test material; the clipped test skin site of one half of the animals was abraded (with a slightly bent tip of a hypodermic needle) by making a series of parallel, epidermal abrasions, every 2 or 3 centimeters longitudinally.
The test site was then covered by wrapping the trunk of each animal with an impervious plastic sleeve which was securely taped in place. This plastic wrap insured close contact of the epidermis and the test material. To prevent oral ingestion of the test material, each animal was fitted with a lightweight, flexible plastic collar which was worn throughout the observation period. Administered as an aqueous slurry.
At the end of the application period the plastic sheeting was taken off and all removable residual test material was washed off with warm tap water. One hour after test material removal, the test skin sites were examined for local skin reactions. - Duration of exposure:
- 24 hours
- Doses:
- 3038 mg/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily observations for motaliy and behavioral abnormalities; weights ere recorded on day 7 and 14
- Clinical signs including body weight
- Other examinations performed: clinical signs, body weight, gross pathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 038 mg/kg bw
- Mortality:
- No mortality.
- Clinical signs:
- other: Diarrhea was observed in rabbit 3-F on the fifth day following dermal exposure to Acetone Sodium Bisulfite. The rabbit did not recover by the sacrifice date.
- Gross pathology:
- Necropsy examination revealed a pale spleen in rabbit 3-F. No other gross pathologic alterations were found, except for the local skin lesions as previously described.
- Other findings:
- The test material was severely irritating to the skin of the albino rabbit. Skin reactions at 24 hours were characterized by red, welldefined erythema, severe edema, subdermal hemorrhages and second degree burns. Superficial escharosis was present at the test skin sites at 7 days and mild desquamation at 14 days.
Any other information on results incl. tables
Dose Level (mg/kg) |
Animal Number and Sex |
Individual body weights (kg) Test Day Number: |
Number dead / Number tested |
Percent Dead |
||
|
|
0 |
7 |
14 |
|
|
3038 |
1-M* |
2.68 |
2.46 |
2.78 |
0/4 |
0 |
|
2-M |
2.70 |
2.82 |
2.96 |
|
|
|
3-F* |
2.78 |
2.56 |
2.52 |
|
|
|
4-F |
3.12 |
3.06 |
3.10 |
|
|
*The skin at the site of application was abraded.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.