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EC number: 866-600-7 | CAS number: 2173997-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October - November, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- See section "Any other information on materials and methods incl. tables"
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- See section "Any other information on materials and methods incl. tables"
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- yes
- Remarks:
- See section "Any other information on materials and methods incl. tables"
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Analysis of the prepared samples was not performed under GLP
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.045 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 20 mg/L
- Incubation duration:
- 96 h
- Temp.:
- 20 °C
- pH:
- 8.48
- Remarks on result:
- other: Average of 72 and 96 hour sample solubility in pure water
- Details on results:
- There is no significant change of the measured concentrations after 72 h and 96 h. Thus it can be concluded that equilibrium is reached. Thus the results obtained after 72 h and 96 h were averaged, to give the water solubility of GR-87-0307.
- Conclusions:
- Solubility of GR-87-0307 in water at 20°C: 0.045 mg/l
- Executive summary:
The solubility of GR-87-0307 in ultrapure water was determined according to the OECD Guideline No. 105 (flask method), based on analysis of the main constituent of GR-87-0307.
The result is:
Solubility in water: 0.045 mg/l at 20°C
This result corresponds to the saturation mass concentration of GR-87-0307 in ultrapure water at 20°C.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- July to September, 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Study performed to determine the functional water solubility of the test item in dechlorinated tap water prior to the performance of a fish bioconcentration study in order to determine what method of exposure should be applied (i.e. aqueous or dietary exposure).
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.08 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- Remarks on result:
- other: to ultrapure water
- Water solubility:
- 0.057 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 24 °C
- Remarks on result:
- other: to dechlorinated tap water
- Details on results:
- The variation of the solubility of consecutive 5 column eluates was within ± 30% in each measurement (each concentration was within 70 to 130% of the average value of 5 measured concentrations (actual observed : 94.2 to 106.3% and 81.9 to 111.3%, respectively, for the 25 mL/hr and 12.5 mL/hr flow rates)). Thus, it was judged that the equilibrium was reached. Then, the water solubilities with flow rate of 25 mL/hr and 12.5 mL/hr were averaged to give the water solubility of the test substance. The water solubility of the test substance to ultrapure water at 20°C was 0.0796 mg/L.
The variation of the solubility of consecutive 5 column eluates was within ± 30% in each measurement (each concentration was within 70 to 130% of the average value of 5 measured concentrations ((actual observed : 88.4 to 110.7% and 93.6 to 117.9%, respectively, for the 100 mL/hr and 50 mL/hr flow rates)). Thus, it was judged that the equilibri-um was reached. Then, the water solubilities with flow rate of 100 mL/hr and 50 mL/hr were averaged to give the water solubility of the test substance. The water solubility of the test substance to dechlorinated tap water at 24°C was 0.0567 mg/L - Conclusions:
- The water solubility of the test substance to ultrapure water (20°C) was calculated to be 0.0796 mg/L.
The water solubility of the test substance to dechlorinated tap water (24°C) was calculated to be 0.0567 mg/L. - Executive summary:
The water solubility measurement of Scentaurus berry was done according to OECD Guideline 105 (Column elution method).
The water solubility of the test substance to ultrapure water (20°C) was calculated to be 0.0796 mg/L.
The water solubility of the test substance to dechlorinated tap water (24°C) was calculated to be 0.0567 mg/L.
Referenceopen allclose all
Description of key information
Key study, OECD 105, GLP, 2018:
The solubility of GR-87-0307 in ultrapure water was determined according to the OECD Guideline No. 105 (flask method), based on analysis of the main constituent of GR-87-0307.
The result is:
Solubility in water: 0.045 mg/l at 20°C
This result corresponds to the saturation mass concentration of GR-87-0307 in ultrapure water at 20°C.
Supporting study, OECD 105, GLP, 2019:
The water solubility measurement of Scentaurus berry was done according to OECD Guideline 105 (Column elution method).
The water solubility of the test substance to ultrapure water (20°C) was calculated to be 0.0796 mg/L.
The water solubility of the test substance to dechlorinated tap water (24°C) was calculated to be 0.0567 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 0.045 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.