1-(2,2,4-trimethyl-3,4-dihydroquinolin-l (2H)-yl)ethanone

Oxidising properties

Administrative data

Endpoint:

oxidising solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

13 Jul - 1 Oct 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test O.3 (Gravimetric test for oxidizing solids)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Hessisches Ministerium für Umwelt, Klimaschutz, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany

Test material

Test material information

Constituent 1

Reference substance name:

1-(2,2,4-trimethyl-3,4-dihydroquinolin-l (2H)-yl)ethanone

EC Number:

855-228-0

Cas Number:

4497-59-0

Molecular formula:

C14 H19 N O

IUPAC Name:

1-(2,2,4-trimethyl-3,4-dihydroquinolin-l (2H)-yl)ethanone

Study design

Contact with:

powdered cellulose

Results and discussion

Test results (Oxidising solids)

Test results (Oxidising solids) 1

Sample tested:

reference: 1:2 mixture calcium peroxide + cellulose

Parameter:

burning rate

Result:

>= 0.22 - <= 0.33 g/s

Remarks on result:

other: The mean burning rate of the mixture of the reference item/cellulose 1:2 was 0.28 g/s.

Test results (Oxidising solids) 2

Sample tested:

1:1 sample-to-cellulose ratio

Parameter:

burning rate

Result:

>= 0.04 - <= 0.06 g/s

Remarks on result:

other: The mean burning rate of the mixture of the test item/cellulose 1:1 was 0.05 g/s.

Test results (Oxidising solids) 3

Sample tested:

4:1 sample-to-cellulose ratio

Parameter:

burning rate

Result:

>= 0.02 - <= 0.03 g/s

Remarks on result:

other: Burning and sooting, The mean burning rate of the mixture of the test item/cellulose 4:1 was 0.03 g/s.

Any other information on results incl. tables

Individual results
The test item contained more than 10 % of particles below 500 µm (see granulometry study M-754106-01-1 in section 4.5 of this IUCLID dossier). Therefore, the test item was ground with mortar and pistil and sieved over a 500 µm sieve. However after four times of grounding and sieving approximately 8 % were still > 500 µm. Therefore, it was considered that the remaining test item was not friable enough and both fractions (>500 µm and <500 µm) were united and taken for the measurement.
The residual moisture of the test item was determined in drying chamber at ambient temperature under vacuum. The test item had a content of residual moisture of 0 % (the test item used for the tests had not been dried).
The ambient temperature was 22 °C and the air humidity was approximately 50 % during the test.
Five tests were performed on the mixture of the reference substance with cellulose in the ratio 1:2. The results are shown in the following table.

Table: Burning times of calcium peroxide/ cellulose mixtures 1:2

Experiment	mCaO2 / g	mcellulose / g	t20-80 / s	BR20-80 / g/s	Observations
1	10.04	20.03	39.75	0.30	-
2	10.01	20.00	93.25	0.31	-
3	10.01	20.00	40.00	0.30	-
4	10.04	20.00	45.75	0.26	-
5	10.01	20.00	55.63	0.22	-

The mean burning rate of the mixture of the reference item/cellulose 1:2 was 0.28 g/s. According to the UN manual the tolerable range is ± 20 % of the mean burning rate (0.22 - 0.33 g/s). The correlation coefficient of the mass loss as a function of time was for all experiments >= 0.90.

Five tests were performed on the mixture of the test item with cellulose in the ratios 4:1 and 1:1 . The results are shown in the following tables.

Table: Burning times of test item/ cellulose mixtures 4:1

Experiment	mtest item / g	mcellulose / g	t20-80 / s	BR20-80 / g/s	Observations
1	24.00	5.99	133.0	0.03	Burning and sooting
2	24.03	6.03	113.8	0.03	Burning and sooting
3	24.01	6.02	145.0	0.02	Burning and sooting
4	24.01	6.00	121.0	0.03	Burning and sooting
5	24.03	6.06	154.9	0.02	Burning and sooting

The mean burning rate of the mixture of the test item/cellulose 4:1 was 0.03 g/s. According to the UN manual the tolerable range is ± 20 % of the mean burning rate (0.02 - 0.03 g/s). The correlation coefficient of the mass loss as a function of time was for each experiment >= 0.90.

 

Table: Burning times of test item/ cellulose mixtures 1:1

Experiment	mtest item / g	mcellulose / g	t20-80 / s	BR20-80 / g/s	Observations
1	15.02	15.01	183.6	0.05	Burning and sooting
2	15.00	15.01	195.1	0.05	Burning and sooting
3	15.00	15.00	189.9	0.05	Burning and sooting
4	15.03	15.00	214.3	0.04	Burning and sooting
5	15.00	15.04	197.3	0.05	Burning and sooting

The mean burning rate of the mixture of the test item/cellulose 1:1 was 0.05 g/s. According to the UN manual the tolerable range is ± 20 % of the mean burning rate (0.04 - 0.06 g/s). The correlation coefficient of the mass loss as a function of time was for each experiment >= 0.90.

 

No tests were performed on the mixture of the reference substance with cellulose in the ratio 3:1 and 1:1 as the test item mixtures were slower than the slowest reference mixture. Due to the fact that the mixtures of test item with cellulose had a slower burning rate than the 1:2 mixture of the reference item, it was concluded that the test item had no oxidizing properties.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The test item, technical substance had no oxidizing properties according to UN Test O.3. The burning rates of the test item mixtures were slower than the burning rate of the 1:2 mixture of the reference item.

Due to these results the test item has not been classified as “oxidising solid”, division 5.1 of the UN manual of Tests and Criteria, revision 7 (2019).

Due to these results the test item has not to be classified as “oxidising solid” according to chapter 2.14 of the CLP regulation and GHS regulation, revision 8.