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EC number: 612-177-7 | CAS number: 61596-96-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to guideline but non-GLP study; However, lots of parameters are documented in raw data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Number of animals
- Principles of method if other than guideline:
- ln principle, the methods described in OECD Guideline 420 were used.
Deviations: Number of test animals - GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Oligomerisation products of But-2-yne-1,4-diol and methyloxirane
- EC Number:
- 612-177-7
- Cas Number:
- 61596-96-1
- Molecular formula:
- (C3 H6 O)m (C3 H6 O)n C4 H6 O2 with 1 ≤ (m+n) ≤ 4.5
- IUPAC Name:
- Oligomerisation products of But-2-yne-1,4-diol and methyloxirane
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Butindiol-mono-propylenglykolether
- Lot/batch No.: no data
- Physical state: liquid
- Purity: 100%
- Density: 1.1 kg/m3
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: average weight female: 170 g, average weight male: 250 g
- Diet (e.g. ad libitum): yes, Altromin R1324 (Altromin GmbH Lage)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2,15% - 4,64%
- Amount of vehicle (if gavage): 10ml
- Justification for choice of vehicle: common vehicle
- Purity: 100%
MAXIMUM DOSE VOLUME APPLIED: - Doses:
- 464 mg/kg, 316 mg/kg, 215 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 minutes, 30 minutes, 1h, 2h, 4h, 5h, 1day - 14 days
- Other examinations performed: clinical signs, body weight, gross pathology
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 250 other: µl/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: purity 100%
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 275 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: purity 100%
- Mortality:
- There were deaths among all doses:
Death/total
Concentration Male Female
4.64% 5/5 5/5
3.16% 3/5 4/5
2.15% 2/5 2/5 - Clinical signs:
- other: - respiratory distress - apathy - in part: abdominal position - ataxia - spastic gait - diarrhea - exsiccosis
- Gross pathology:
- Heart: acute dilatation and accumulation of blood
Liver: periphere lobular enlargement and soft consistency
Kidney: bright cortex
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information GHS (EU) Criteria used for interpretation of results: EU
- Conclusions:
- Acute oral toxicity yields to an LD50 of 275 mg/kg bw and therefore the test substance should be classified as acute oral toxic categorie 3 (GHS) (BASF, 1980)
- Executive summary:
ln principle, the methods described in OECD Guideline 420 were used without GLP compliance.
5 rats per sex and dose were treated simultaneously with concentrations of 464 mg/kg, 316 mg/kg, 215 mg/kg by gavage
with preparations of the test substance in water as vehicle.
Group-wise documentation of clinical signs was performed over the 14- day study period, where clinical signs and mortality was documented, which was observed among all doses.
On the basis of the observed lethality, the LD50 value was estimated to be 250µl/kg bw, which is in accordance with 275mg/kg and as a conseqence of it, the test substance should be classified as acute oral toxic categorie 3 (GHS). (BASF, 1976)
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