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EC number: 254-879-2 | CAS number: 40306-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11.-13.05.1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Code number: FAT - 92'333/A
Batch number: K 37/19.5.92
Purity: 97.2 %
Appearance: solid
Solubility: 1.3 g/l in water
Storage: room temperature
Expiration date: 01.06.93
Reference substance:
Potassium dichromate (EC50: 0.93 mg/l) - Analytical monitoring:
- yes
- Details on sampling:
- The concentration of the test substance at the beginning and at the end of the test was analysed by the Analytical Services K, Textile Dyes Division. All test medium samples for the analytical determinations were taken after mixing of the test solutions.
- Vehicle:
- no
- Details on test solutions:
- test article in 250 ml beakers containing 100 - 200 ml
test medium with 10 animals per beaker
The test water medium was prepared with bidistilled water.
The pH is in a range of 7.8 - 8.2
The medium was oxygen saturated at the beginning of the test. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Test system / Test organism
The test organism was the species Daphnia magna. The daphnids were bred in the laboratories of the Textile Dyes Division, Product Ecology TF under standardized conditions. For the test, animals with age of less than 24 hours were used. The quality of the daphnids will be checked at least every 3 months by determining the EC50 values (24 h) for potassium dichromate (range: 0,8 -1,5 mg/l). For each concentration, 20 Daphnia magna were used.
Experimental conditions
48 hours at 21 °C, 16 h light / 8 hours dark
The daphnids were exposed to the test article in 250 ml beakers containing 100 - 200 ml test medium with 10 animals per beaker. All tests are running in duplicate. During exposure, the animals were kept at 21 ± 1 °C with 16 hours illumination. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- 48 h
- Hardness:
- Theoretical water hardness : 136 mg/l CaCCO3
Ca / Mg ratio 4:1
Na/K ratio 10:1
alkalinity 0.8 mmol/l - Test temperature:
- start 22 °C
- pH:
- 7.7
- Dissolved oxygen:
- saturated
- Details on test conditions:
- End: Nominal cone, (mg/l) 58; 100; 180; Blank
Oxygen (%) 97; 95; 93; 99;
pH 7.8; 7.5; 7.7; 8.1;
Temperature (°C) 20.6; 20.6; 20.6; 20.6;
The test medium used had the following composition:
stock solution concentration:
NaHCOs: 65 mg/l
MgS04 * 7H2O: 127.5mg/l
KCL: 5.9 mg/l
CaCl2 * 2 H2O: 294
SeO2: 1.4 µg/l
NaBr: 16.1µg/l
Vitamine B 12: 1.0 µg/l
The test water medium was prepared with bidistilled water.
The pH is in a range of 7.8 - 8.2
The medium was oxygen saturated at the beginning of the test.
Theoretical water hardness: 136mg/l CaCOs
Ca / Mg ratio: 4: 1
Na / K ratio: 10:1
alkalinity: 0.8 mmol/l - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate, EC50=0.93 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 134.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Remarks:
- not toxic to daphnia
- Conclusions:
- FAT - 92'333/A is considered to be practically non toxic to daphnids.
- Executive summary:
The acute toxicity of test substance to Daphnia magna was determined in a 48-hour static test according to the OECD Guideline for Testing of Chemicals, Section 2, No. 202, adapted 4 April 84, and EEC Directive 84/449, L 251, Part C 2. The test was performed in compliance with the Good Laboratory Practice Regulations. The nominal concentrations tested were 58, 100 and 180 mg test article/l, and a control without any additions. In the freshly prepared test medium 78.7 - 87.2 % of the nominal test concentrations was analytically determined. After 48 hours 67.2 - 72.5 % of the nominal test concentrations was found in the test medium. In the stock solution and in all test concentrations the test substance was dissolved without any sedimentation or flocculation. Since the analyzed concentrations were clearly lower than the nominal concentrations the mean values were calculated between the measured concentrations of the start and the end of the test.The EC-values reported are related to the mean measured concentrations of the test substance. In the control no immobilization of the daphnids was observed after 48 hours. The EC0 value could not be calculated, but is lower than 42.5 mg/l.
The EC50 value was calculated to be 134.8 mg/l.
Results:
EC0: <42.5 mg/L
EC50: 134.8 mg/L
EC100: >134.2 mg/L
Conclusion : FAT - 92'333/A is practically non toxic to Daphnia magna.
Reference
Oxygen concentration and pH
The oxygen concentration and the pH was controlled at the beginning and at the end of the test.
Start:
Oxygen: - saturated
pH: 7.7 (stock solution]
Temperature: 22°C
End:
Nominal conc, (mg/l)
|
58
|
100
|
180
|
Blank
|
Oxygen (%)
|
97
|
95
|
93
|
99
|
pH
|
7.8
|
7.5
|
7.7
|
8.1
|
Temperature (°C)
|
20.6
|
20.6
|
20.6
|
20.6
|
Immobilization of Daphnids
The results of the study are given in table 1.
Table 1
Conc, of Test substance
(mg/l actual)
|
No. of animals
|
No. of responses 24 h |
No. of responses 48 h |
% immobility 24 h
|
% immobility 48 h
|
Blank
|
10 10 |
0 0 |
0 0 |
0 |
0 |
42.5
|
10 10 |
0 0 |
0 1 |
0 |
5 |
79.9
|
10 10 |
0 0 |
1 3 |
0 |
20 |
134.2
|
10 10 |
0 0 |
5 5 |
0 |
50 |
Calculation of EC - values
Influence of FAT-92'33/A on Daphnia magna after 48 hours of exposure. In the freshly prepared test medium 78.7 - 87.2 % of the nominal test concentrations was analytically determined. After 48 hours 67.2 - 72.5 % of the nominal test concentrations was found in the test medium. In the stock solution and in all test concentrations the test substance was dissolved without any sedimentation or flocculation. Since the analyzed concentrations were clearly lower than the nominal concentrations the mean values were calculated between the measured concentrations of the start and the end of the test. The EC - values reported are related to the mean measured concentrations of the test
substance. In the control no immobilization of the daphnids was observed after 48 hours. The EC0 value could not be calculated, but is lower than 42.5 mg/l. The EC50 value was calculated to be 134.8 mg/l.
The EC values are evaluated as follows: (mg/l)
|
EC0 |
EC 50 |
EC100 |
after 24 h |
> 134.2
|
> 134.2
|
> 134.2
|
after 48 h |
<42.5
|
134.8* |
> 134.2
|
*The EC50 values are calculated with the LOGIT MODEL.
95 % confidence limit (48 h): 104.8 - 285.9
Description of key information
The acute toxicity of FAT - 92'333/A to Daphnia magna was detennined in a 48-hour static test according to the OECD Guideline for Testing of Chemicals, Section 2, No. 202, adapted 4 April 84, and EEC Directive 84/449, L 251, Part C 2. The EC50 was determined to 134.8 mg/L which means that the test item is practically non-toxic to aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 134.8 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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