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Diss Factsheets
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EC number: 461-290-6 | CAS number: 167374-38-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Valid without restriction
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- Name of the test substance: 505-Oximether
Purity: 84.7 % w/w
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test concentration was prepared by diluting an acetonic stock solution with dilution water.
The stock solution was prepared by weighing 0.0506 g test substance and diluting it in 100
mL acetone. This stock solution was further diluted with acetone to recieve stock solutions for
each test concentration (see scheme below). The required amount of the acetonic stock
solution was given into the test vessel. After evaporating of the acetone the test vesseis wer~
filled with test water. The test substance was dissolved in the test water using an ultra turraxl.*
lt was tried to maximize the recovery rates by a prolonged stirring period of 5 days before the
fish were inserted into the test solutions to reach the maximum solubility, since an increase in
the test concentrations was observed in another aquatic study over 3 days. However, in this
test no marked increase was observed during the 5 days stirring period and a decrease of
the concentrations was observed at the end of the exposure period.
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): acetone
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- - Test species: Zebrafish (Danio rerio)
- Animal suppier: Zierfisch-Center Klöckner, Ludwigshafen, Germany
- Body weight (wet weight): 0.30 g (0.24 - 0.42 g)
- Body length (from the top of the snout 3.3 cm (3.1 - 3.6 cm) to the end of the caudal fin):
- Age of the animals: Approx. 4 months
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Details on test conditions:
- - Dilution water source: Municipal water of the city of Frankenthal, not chlorinated and passed through a charcoal filter.
- Total hardness: about 1 mmol/l
Acid capacity: about 2.5 mmol/l
pH: 7.5 - 8.5
Ca content : about 40 mg/l
Mg content : about 5 mg/l
- Exposure vessel type: Test vessels: All glass aquaria (30 x 22 x 24 cm)
- Volume of water: 10 l
- Aeration: Continuous aeration with oil-free air, slight
- Photoperiod: 16 : 8 hours day-night regime
- One test vessel per treatment
- Number of animals per test concentration and control: 10
- pH during the test: 7.8 - 8.2
- Oxygen content during the test: 7.9 - 8.8 mg/l
- Water temperature: 22 - 23 °C;
- Duration of adaption: about 2 weeks Mortality during the adaption period: 0 %
- Withdrawal of food: 1 day before and during exposure. - Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 0.066 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.041 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 0.026 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Any other information on results incl. tables
- Sublethal observations / clinical signs:
- RS-Freetext:
Nominal concentrations (mg/l): 0.022, 0.05, 0.1, 0.22 and 0.5
An analytical dose-verification of the test item was carried out at day 1.
Nom. Conc. (mg/l) Mean Anal. Conc. (mg/l) % of Nom. Conc.
0 n.d. -
0.022 < loq -
0.05 0.0103 20.6
0.1 0.0188 18.8
0.22 0.0394 17.9
0.5 0.1047 20.9
(n.d. = not detectable, loq = limit of quantification)
LC 50 (48h): 0.041 mg/l
LC 50 (72h): 0.041 mg/l
LC 50 (96h): 0.041 mg/l
Biological observations:
St = stottering, D = swimming at the bottom, C = swimming at the surface, A = apathy
Table showing cumulative mortality:
Cumulative mortality
Nom. conc. (mg/l) 1h 4h 24h 48h 72h 96h
Control 0 0 0 0 0 0
0.022 0 0 0 0 0 0
0.05 0 0 0 0 0 0
0.1 0 0 0 0 0 0
0.22 0 0 0 0 0 0
0.5 0 3 8 10 10 10
Behavior of the test item during the test: No remarkable observations
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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