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EC number: 701-234-2 | CAS number: 18402-84-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-04-16 to 2009-07-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- (3E)-dec-3-en-2-one
- Cas Number:
- 18402-84-1
- Molecular formula:
- C10H18O
- IUPAC Name:
- (3E)-dec-3-en-2-one
- Details on test material:
- - CAS: 18402-84-1
- Purity: 98.57% to 99.11% w/w
- Batch No.: Lot KB 147-36-1
- Physical state: liquid
- Colour: Colorless to pale yellow
- Storage conditions: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Received from Ace Animals, Inc., Boyertown, PA on April 21, 2009.
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: 8-9 weeks
- Weight at study initiation: 217 - 238 g (males) and 182 - 208 (females)
- Housing: The animals were singly housed in suspended stainless steel caging with mesh floors, which conform to the size recommendations in the most recent Guide for the Care and Use of Laboratory Animals DHEW (NIH). Litter paper was placed
beneath the cage and was changed at least three times per week.
- Diet (e.g. ad libitum): Purina Rodent Chow #5012
- Water (e.g. ad libitum): Filtered tap water ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-23
- Humidity (%): 51-66
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 2 x 3 inches
- % coverage: 10% of the body surface
- Type of wrap if used: 3-inch Durapore tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not specified, but the test sites were gently cleansed of any residual test substance
- Time after start of exposure: 24 hrs
TEST MATERIAL
- Amount(s) applied : 5000 mg/kg bw
VEHICLE
- Amount(s) applied : none - Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Application of Test Substance:
Five thousand mg/kg of body weight of the test substance was applied evenly over a dose area of approximately 2 inches x 3 inches (approximately 10% of the body surface) and covered with a 2-inch x 3-inch, 4-ply gauze pad. The gauze pad and entire trunk of each animal were then wrapped with 3-inch Durapore tape to avoid dislocation of the pad and to minimize loss of the test substance. The rats were then returned to their designated cages. The day of application was considered Day 0 of the study.
After 24 hours of exposure to the test substance, the pads were removed and the test sites were gently cleansed of any residual test substance.
Body Weights:
Individual body weights of the animals were recorded prior to test substance application (initial) and again on Days 7 and 14 (termination) or after death.
Cage-Side Observations:
The animals were observed for mortality, signs of gross toxicity, and behavioral changes during the first several hours after application and at least once daily thereafter for up to 14 days or until death occurred. Observations included gross evaluation of skin and fur, eyes and mucous membranes, respiratory, circulatory, autonomic and central nervous systems, somatomotor activity and behavior pattern. Particular attention was directed to observation of tremors, convulsions, salivation, diarrhea, and coma.
Necropsy:
Surviving rats were euthanized via C02 inhalation at the end of the 14-day observation period. Gross necropsies were performed on decedent and euthanized animals. Tissues and organs of the thoracic and abdominal cavities were examined. - Statistics:
- N.a.
Results and discussion
- Preliminary study:
- N.a.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One female died within two days of test substance application. Prior to death, this animal was hypoactive and exhibited prone posture.
- Clinical signs:
- other: The animal survivors were also hypoactive, but recovered by Day 2. Dermal irritation was noted at the dose site of all surviving animals between Days 1 and 14.
- Gross pathology:
- No abnormalities were observed at gross necropsy for the animals which survived until termination at day 14. Extremely red intestines were observed at gross necropsy for the animal which died during the study.
- Other findings:
- N.a.
Any other information on results incl. tables
Table 1: Mortality of tests animals
Dose (mg/kg bw) |
Males |
Females |
Combined |
5000 |
0/5 |
1/% |
1/10 |
Table 2: Clinical observations
Observation |
Males |
Females |
Mechanical damage due to unwrapping |
5/5 |
5/5 |
Hypoactivity |
4/5 |
4/5 |
Erythema |
4/5 |
4/5 |
Light pink stain at dose site |
5/5 |
5/5 |
Desquamation |
5/5 |
3/5 |
Hyperkeratosis |
0/5 |
1/5 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute dermal toxicity study in rats conducted according to OECD 402, one female died within two days at a dose of 5000 mg/kg bw. Based on the results and in accordance with OECD guideline 402 the LD50 value was determined to be greater than 5000 mg/kg bw in male and female rats. Thus, the substance does not warrant classification as being toxic or harmful based upon its acute dermal toxicity.
- Executive summary:
An acute dermal toxicity test was conducted in accordance with OECD test guideline 402 to determine the potential of (3E)-dec-3-en-2-one to induce acute dermal toxicity in male and female Sprague-Dawley rats. 5000 mg/kg bw was applied to the skin of 5 rats per sex for 24 hours. The animals were observed for mortality, signs of gross toxicity, and behavioural changes at least once daily for up to 14 days. Body weights were recorded prior to application and again on Days 7 and 14 (termination) or after death. Necropsies were performed on all animals.
One female died within two days of test substance application. Prior to death, this animal was hypoactive and exhibited prone posture. Seven survivors were also hypoactive but recovered by Day 2. Dermal irritation was noted at the dose site of all surviving animals between Days 1 and 14. Gross necropsy of the decedent revealed extremely red intestines. No gross abnormalities were noted for the euthanized animals when necropsied at the conclusion of the 14-day observation period. Under the conditions of this study, the single dose acute dermal LD50 of the test item is greater than 5000 mg/kg bw in male and female rats.
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