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Diss Factsheets
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EC number: 950-576-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance does not meet the criteria for classification as acute toxicity or STOT SE by the oral route and no systemic effects have been observed in in vivo studies with dermal exposure (e.g. skin irritation, skin sensitisation)
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
According to conditions described in Column 2 of Section 8.5.3 of Annex VIII testing by the dermal route is appropriate if: (1) inhalation of the substance is unlikely; and (2) skin contact in production and/or use is likely; and (3) the physicochemical and toxicological properties suggest potential for a significant rate of absorption through the skin. Since SHR 1396 is only used in hermetically sealed compressors skin contact in production and/or use is unlikely to result in exposure to SHR 1396. Since SHR 1396 is expected to have limited absorption through the skin based on its low water solubility (0.04 mg/L) and high Log Pow (7.0 – 7.2), showed no systemic effects in an in vivo study (LLNA) with dermal exposure and has already low acute oral toxicity it is unlikely that the acute dermal toxicity will exceed the oral toxicity. Since criteria (2) and (3) in Column 2 of section 8.5.3 of Annex VIII are not fulfilled, testing by the dermal route for SHR 1396 is considered not appropriate and thus testing is waived.
See Cross references for relevant supporting data on uses, toxicological data and physical and chemical properties.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 Jul - 06 Aug 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- 2010
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2600 (Skin Sensitisation)
- Version / remarks:
- 2003
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- 2012
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- CBA:J
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Janvier, Le Genest-Saint-Isle, France.
- Females nulliparous and non-pregnant: yes.
- Microbiological status of animals: SPF-quality.
- Age at study initiation: 10 weeks old.
- Weight at study initiation: 19.6 to 23.0 grams.
- Housing: Animals were group housed (up to 5 animals of the same sex and same dosing group together) in polycarbonate cages (Makrolon MIII type; height 18 cm.) containing sterilized sawdust as bedding material (Lignocel S 8-15, JRS - J.Rettenmaier & Söhne GmbH + CO. KG, Rosenberg, Germany) equipped with water bottles.
- Diet: Pelleted rodent diet (SM R/M-Z from SSNIFF® Spezialdiäten GmbH, Soest, Germany), ad libitum.
- Water: Municipal tap-water was freely available to each animal via water bottles.
- Acclimation period: at least 5 days.
- Indication of any skin lesions: no.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): The daily mean temperature during the study period was 22 to 23°C.
- Humidity (%): The daily mean relative humidity of 53 to 79%.
- Air changes (per hr): at least 10.
- Photoperiod (hrs dark / hrs light): 12/12
- IN-LIFE DATES: From 17 Jul to 05 Aug. - Vehicle:
- acetone/olive oil (4:1 v/v)
- No. of animals per dose:
- 5 animals
- Details on study design:
- PRE-SCREEN TESTS:
Two test item concentrations were tested; a 50% (w/w) and 100% (w/w) concentration.
Two young adult females per concentration were selected. Each animal was treated with one concentration on three consecutive days. Ear thickness measurements were conducted using a digital thickness gauge (Kroeplin C110T-K) prior to dosing on Days 1 and 3, and on Day 6. Animals were sacrificed after the final observation.
MAIN STUDY
Three groups of five animals were treated with one test item concentration per group. The highest test item concentration was selected from the pre-screen test. One group of five animals was treated with the vehicle.
Group 1 was treated with the vehicle (vehicle control group). Group 2, 3 and 4 were treated with 25%, 50% and 100% concentration, respectively.
TREATMENT PREPARATION AND ADMINISTRATION:
Test item dosing formulations (w/w) were homogenized to visually acceptable levels at appropriate concentrations to meet dose level requirements.
The dosing formulations were prepared daily and dosed within 4 hours after adding the vehicle to the test item.
The dosing formulations were kept at room temperature until dosing.
The dosing formulations were stirred until and during dosing.
No adjustment was made for specific gravity of the vehicle and no correction was made for the purity/composition of the test item.
- Induction: Test item (25 μL) was applied in the dorsal surface of both ears of each animal, for 3 consecutive days.
- Excision of the Nodes. In day 6, each animal was injected via the tail vein with 0.25 mL of sterile phosphate buffered saline (PBS) containing 20 μCi of 3H-methyl thymidine. After five hours, all animals were euthanized by intraperitoneal injection (0.2 mL/animal) of Euthasol® 20%. The draining (auricular) lymph node of each ear was excised. The relative size of the nodes (as compared to normal) was estimated by visual examination and abnormalities of the nodes and surrounding area were recorded. The nodes were pooled for each animal in PBS.
- Tissue processing for radioactivity: On day 6 and following the excision of the nodes, a single cell suspension of limph node cells was prepared in PBS. LNC were washed twice and DNA was precipitated using 5% trichloroacetic acid (TCA).
- Radioactivity measurements: On day 7, precipitates were recovered by centrifugation, resuspended in 1 mL TCA and transferred to 10 mL of Ultima Gold cocktail as the scintillation fluid. Radioactivity measurements were performed using a Packard scintillation counter (2910TR). Counting time was to a statistical precision of ± 0.2% or a maximum of 5 minutes whichever came first. The scintillation counter was programmed to automatically subtract background and convert Counts Per Minute (CPM) to Disintegrations Per Minute (DPM).
ANALYSIS
DPM values are presented for each animal and for each dose group. A Stimulation Index (SI) is calculated for each group using the individual SI values. The individual SI is the ratio of the DPM/animal compared to the DPM/vehicle control group mean.
INTERPRETATION
If the results indicate a SI ≥ 3, the test item may be regarded as a skin sensitizer.
The results were evaluated according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2017) (including all amendments) and the Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of items and mixtures, including all amendments.
Consideration was given to the EC3 value (the estimated test item concentration that will give a SI =3) (see table 1 in 'any other information on material and methods') - Key result
- Parameter:
- SI
- Value:
- 1.9
- Test group / Remarks:
- 25%
- Key result
- Parameter:
- SI
- Value:
- 2.4
- Test group / Remarks:
- 50%
- Key result
- Parameter:
- SI
- Value:
- 2.5
- Test group / Remarks:
- 100%
- Cellular proliferation data / Observations:
- PRE-SCREENING TEST:
- At a 50% and 100% test item concentration, no signs of systemic toxicity were noted and up to very slight erythema was observed and therefore the 100% concentration was selected as highest concentration for the main study.
MAIN STUDY
SKIN REACTIONS / IRRITATION:
The very slight erythema of the ears as shown by all test item treated animals on at 1 to 6 Days during the observation period was considered not to have a toxicologically significant effect on the activity of the nodes.
CLINICAL OBSERVATIONS: No mortality occurred and no clinical signs of systemic toxicity were observed in the animals.
BODY WEIGHTS: Body weights and body weight gain of experimental animals remained in the same range as controls over the study period.
MACROSCOPIC EXAMINATION OF LyMPH NODES:
The majority of auricular lymph nodes were considered normal in size, except for the nodes in two animals treated at 100%, which were considered to be slightly enlarged.
No macroscopic abnormalities of the surrounding area were noted for the majority of animals. Pale discoloration of the surrounding area of the lymph nodes of the animals treated at 100% was noted, which was considered not to have affected the DPM values of these animals.
DETAILS ON STIMULATION INDEX CALCULATION : DPM (Disintegrations Per Minute) values are presented for each animal and for each dose group. A Stimulation Index (SI) is calculated for each group using the individual SI values. The individual SI is the ratio of the DPM/animal compared to the DPM/vehicle control group mean.
- Interpretation of results:
- other: Not skin sensitising
- Remarks:
- According to Regulation (EC) No. 1272/2008 and its amendments.
- Conclusions:
- In conclusion, since there is no indication that the test item elicited a SI ≥ 3 when tested up to 100%, SHR 1396 was considered not to be a skin sensitizer.
- Executive summary:
A LLNA study was performed following OECD guidelines and GLP principles. Three experimental groups of five females were treated with test item concentrations of 15%, 50% and 100%. One control group of five females was treated with the vehicle (Acetone/olive oil 1:4 v/v). All animals were treated for 3 consecutive days. Three days after the last exposure all animals were injected with 3H-methyl thymidine for measuring radioactivity. The activity was expressed as the number of disintegrations per minute (DPM) and a stimulation index (SI) was calculated for each group. The six-month reliability check with Alpha-hexylcinnamaldehyde indicates that the Local Lymph Node Assay as performed at Charles River Den Bosch is an appropriate model for testing for contact hypersensitivity. No macroscopic abnormalities of the surrounding area were noted for the majority of animals. Pale discoloration of the surrounding area of the lymph nodes of the animals treated at 100% was noted, which was considered not to have affected the DPM values of these animals. Mean DPM/animal values for the experimental groups treated with test item concentrations 25, 50 and 100% were 717, 938 and 972 DPM, respectively. The mean DPM/animal value for the vehicle control group was 384 DPM. The SI values calculated for the test item concentrations 25, 50 and 100% were 1.9, 2.4 and 2.5, respectively. Since there was no indication that the test item elicited a SI ≥ 3 when tested up to 100%, SHR 1396 was considered not to be a skin sensitizer. Based on these results, SHR 1396 would not be regarded as a skin sensitizer according to the recommendations made in the test guidelines. The test item does not have to be classified and has no obligatory labelling requirement for sensitization by skin contact according to Regulation (EC) No 1272/2008 on classification, labelling and packaging of items and mixtures (including all amendments).
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.18 mg/m³
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Dose descriptor starting point:
- NOAEL
- Value:
- 100 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 176 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Kinetics (metabolism, distribution and excretion) are considered to be similar for oral and inhalation intake in the absence of evidence of the opposite.
Starting point: NOAEL of 100 mg/kg bw/day in a 28-day combined repeated dose repro screener toxicity study in rat.
Conversion of an oral NOAEL into a corrected NOAEC:
For workers (8h exposure/day), the corrected inhalatory NOAEC = oral NOAEL * 1/sRVrat * ABSoral-rat /ABSinhal-human * sRVhuman/wRV
= 100 * 1/0.38 m3/kg/8h * ABSoral-rat /ABSinhal-human * 6.7 m3(8h)/10 m3(8h)
= 100 * 1/0.38 m3/kg/8h * 1 * 6.7 m3 (8h)/10 m3(8h)
= 100 /0.38 * 1* (6.7/10) = 176.3 mg/m3.
With ABS: Absorption, sRV: Standard Respiratory Volume; wRV: Worker Respiratory Volume; ABSoral-rat /ABSinhal-human= 50/50= 1, assuming no differences in inhalation absorption between rats and humans.
- AF for dose response relationship:
- 2
- Justification:
- Value is NOAEL. An additional factor 2 is included to take account of the lower sensitivity the OECD 422 study for fertility effects.
- AF for differences in duration of exposure:
- 6
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 5
- Justification:
- Default (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.833 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEL
- Value:
- 100 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 500 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Kinetics (metabolism, distribution and excretion) are considered to be 50% for oral and 10% for dermal intake.Correction dermal NOAEL: 50/10a= 500 mg/kg bw/day (a% oral/dermal absorption)
- AF for dose response relationship:
- 2
- Justification:
- Value is NOAEL. An additional factor 2 is included to take account of the lower sensitivity the OECD 422 study for fertility effects
- AF for differences in duration of exposure:
- 6
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 5
- Justification:
- Default (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.29 mg/m³
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Dose descriptor starting point:
- NOAEL
- Value:
- 100 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 87 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Kinetics (metabolism, distribution and excretion) are considered to be similar for oral and inhalation intake in the absence of evidence of the opposite.
Starting point: NOAEL of 100 mg/kg bw/day in a 28-day combined repeated dose repro screener toxicity study in rat.
Conversion of an oral NOAEL into a corrected NOAEC:
For general population (24h exposure/day), the corrected inhalatory NOAEC = oral NOAEL * 1/sRVrat * ABSoral-rat /ABSinhal-human
= 100 * 1/1.15 m3/kg/d * ABSoral-rat /ABSinhal-human
= 100 * 1/1.15 m3/kg/d * 1
= 100 /1.15 * 1 = 87.0 mg/m3
With ABS: Absorption, sRV: Standard Respiratory Volume; ABSoral-rat /ABSinhal-human= 50/50= 1, assuming no differences in inhalation absorption between rats and humans.
- AF for dose response relationship:
- 2
- Justification:
- Value is NOAEL. An additional factor 2 is included to take account of the lower sensitivity the OECD 422 study for fertility effects.
- AF for differences in duration of exposure:
- 6
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 10
- Justification:
- Default (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.417 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 1 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 100 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 500 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Kinetics (metabolism, distribution and excretion) are considered to be 50% for oral and 10% for dermal intake.Correction dermal NOAEL: 50/10a= 500 mg/kg bw/day (a% oral/dermal absorption)
- AF for dose response relationship:
- 2
- Justification:
- Value is NOAEL. An additional factor 2 is included to take account of the lower sensitivity the OECD 422 study for fertility effects.
- AF for differences in duration of exposure:
- 6
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 10
- Justification:
- Default (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 83.3 µg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 1 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 100 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 100 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- AF for dose response relationship:
- 2
- Justification:
- Value is NOAEL. An additional factor 2 is included to take account of the lower sensitivity the OECD 422 study for fertility effects.
- AF for differences in duration of exposure:
- 6
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 10
- Justification:
- Default (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
- Hazard assessment conclusion:
- no hazard identified
- Hazard assessment conclusion:
- no hazard identified
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Registration/ Notification status for the use:
- use registered according to REACH Article 10; total tonnage manufactured/imported >=10tonnes/year per registrant
- Use name:
- Use at industrial site by the registrant
- Name of activity / technique:
- Use of the substance
- Environmental release category (ERC):
- ERC5: Use at industrial site leading to inclusion into/onto article
- Name of activity / technique:
- Use of the substance
- Process category (PROC):
- PROC 1: Chemical production or refinery in closed process without likelihood of exposure or processes with equivalent containment conditions
- Substance supplied to that use in form of:
- as such
- Subsequent service life relevant for this use:
- yes
- Related assessment:
- use assessed in an own CSR
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint conclusion:
- no adverse effect observed
- Endpoint conclusion:
- no study available
- Endpoint conclusion:
- no study available
In an acute oral toxicity study with female rats, performed according to OECD 423 and GLP principles, a LD50 >2000 mg/kg bw was determined.
The determination of Acute inhalation toxicity and Acute Dermal toxicity is waived based on exposure considerations and the physicochemical and toxicological properties of SHR 1396.
An acute oral toxicity study was performed according to OECD 423 test guideline and GLP principles. SHR 1396 was administered by oral gavage to two consecutive groups of three female Wistar Han rats at 2000 mg/kg body weight. No mortality occurred. Hunched posture and/or piloerection was noted for all animals between Days 1 and 5. The mean body weight gain shown by the animals over the study period was considered to be similar to that expected for normal untreated animals of the same age and strain. No abnormalities were found at macroscopic post mortem examination of the animals. Based on these results, a LD50 >2000 mg/kg body weight was determined.
Based on the current available information, the substance does not have to be classified for acute toxicity according to the CLP Regulation.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.