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EC number: 817-766-4 | CAS number: 91891-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- Deviations:
- no
- Remarks:
- No deviations ocurred that would have impacted the integrity of the results of the study.
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- no
Test material
- Reference substance name:
- 1,1,2,3,3-pentafluoro-3-(heptafluoropropoxy)prop-1-ene
- EC Number:
- 817-766-4
- Cas Number:
- 91891-42-8
- Molecular formula:
- C6F12O
- IUPAC Name:
- 1,1,2,3,3-pentafluoro-3-(heptafluoropropoxy)prop-1-ene
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 3M Company
- Expiration date of the lot/batch: No data
- Purity test date: 05 Feb, 2018
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature and humidity, protected from light and stored under enert gas
- Stability under test conditions: Stable
TREATMENT OF TEST MATERIAL PRIOR TO TESTING : None, dosed unchanged
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
- Females (if applicable) nulliparous and non-pregnant: Yes
- Age at study initiation: Approximately 4-5 weeks
- Weight at study initiation: 174-216 grams
- Fasting period before study: 16-20 hours prior to dosing
- Housing: The animals were individually housed in suspended wire-bottom cages.
- Diet (e.g. ad libitum): resh PMI Rat Chow (Diet No.5012) was available ad libitum except for 16-20 hours prior to dosing.
- Water (e.g. ad libitum): Water was available ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): "Temperature controlled"
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 10 July 2018 To: 22 August 2018
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE: None
MAXIMUM DOSE VOLUME APPLIED: No data - Doses:
- 175, 550, 2000 mg/kg body weight
- No. of animals per sex per dose:
- 175 mg/kg (1 female), 550 mg/kg (1 female), 2000 mg/kg (3 females)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed at 15 minutes, 1, 2 and 4 hours post-dosing and once daily thereafter for 14 days for toxicity and pharmacological effects. Body weights were recorded pre-test, weekly, and at termination.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology upon necropsy
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- other: 175 mg/kg: No abnormal clinical signs were noted. 550 mg/kg: Piloerection was observed. 2000 mg/kg: Abnormal physical signs including diarrhea, partially chewed food, wet anogenital area, piloerection, diminished fecal output, chromorhinorrhea, nose/mouth
- Gross pathology:
- No abnormal gross pathological findings were noted upon necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of the study, the oral LD50 of the test article is greater than 2,000 mg/kg body weight.
- Executive summary:
The acute oral lethality potential of the test article was evaluated in female Sprague Dawley rats. The study was conducted according to OECD 425 in compliance with OECD GLP regulations. A single female rat was dosed via oral gavage with 175 mg/kg body weight of the test article. Since the rat survived, an additional female was dosed with 550 mg/kg. As those rats both survived, a group of three female rats were dosed with 2,000 mg/kg. Animals were observed at 15 minutes, 1, 2 and 4 hours post-dosing and once daily thereafter for 14 days for toxicity and pharmacological effects. Body weights were recorded pre-test, weekly, and at termination. No mortality occurred during the study. Piloerection was observed in the 550 mg/kg rat and diarrhea, partially chewed food, wet anogenital area, piloerection, diminished fecal output, chromorhinorrhea, nose/mouth area stained red and thinning hair on the right and left hind limbs were observed in the rats dosed with 2,000 mg/kg. Based on the results of the study, the oral LD50 of the test article is greater than 2,000 mg/kg body weight.
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