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Diss Factsheets
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EC number: 612-381-6 | CAS number: 61789-91-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The EpiAirway™ Model provided by MatTek Corporation (Ashland, MA, USA)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- no defined IUPAC name
- EC Number:
- 612-381-6
- Cas Number:
- 61789-91-1
- Molecular formula:
- no molecular structure defined
- IUPAC Name:
- no defined IUPAC name
- Test material form:
- semi-solid (amorphous): gel
- Details on test material:
- Components Floraesters 30
Wax Ester ---
36:2 <2
38:0 <1
38:1 2 - 4
38:2 2 - 4
40:0 2 - 4
40:1 14 - 18
40:2 17 - 21
42:0 2 - 4
42:1 14 - 18
42:2 17 - 21
44:0 <2
44:1 4 - 7
44:2 4 - 7
46:2 <3
Iodine Value** 57 - 61
Mono-ester content*** 40 - 47
Constituent 1
Results and discussion
- Preliminary study:
- The test articles: Jojoba Esters and, Isopropyl Jojobate and Jojoba Alcohol and Jojoba Esters, and Hydrolyzed Jojoba Esters, negative control (sterile deionized water) and positive control (14.7 mg/mL formaldehyde) were tested in the preliminary assay (16 May 2018).
At least 16 hours after initiating the tissues, the medium was removed from under the tissue and replaced with 1 mL of fresh pre-warmed AM. Immediately after refeeding, the tissues’ apical surface was rinsed twice with 0.4 mL of sterile Ca++Mg++Free-DPBS (CMF-DPBS) (warmed at 37°C) to remove a mucus layer that may be coating the apical surface of the tissues. The CMF-DPBS was added slowly to the apical side of the tissue (directed at the side of the cell culture insert, i.e. not directly onto the tissue surface) and then gently aspirated. The tissues were inverted and gently blotted on sterile absorbent to remove excess moisture.
Three concentrations (500, 250, and 50 mg/mL) were selected for each test article. One hundred μL of each test article were applied in a single EpiAirway™ tissue per concentration for 3 hours. A single tissue was treated with 100 μL of the negative and positive control for 3 hours. The tissues were incubated at standard culture conditions before being transferred to MTT.
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- other: EC75
- Effect level:
- >= 150 other: mg/mL
- Based on:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute inhalation toxicity potential of the test articles were evaluated in EpiAirway™ tissues using the methods and prediction model presented by MatTek.
All tested concentrations of the test articles: Jojoba Esters, Isopropyl Jojobate and Jojoba Alcohol and Jojoba Esters, and Hydrolyzed Jojoba Esters resulted in relative viabilities of ~100%, and therefore the EC75 was presented as greater than the highest tested dose.
According to the prediction models, an EC75 value greater than 150 mg/mL or 200 mg/mL would be consistent with an EPA Category IV or GHS Category 4-5, respectively. The test articles: Jojoba Esters, Isopropyl Jojobate and Jojoba Alcohol and Jojoba Esters, and Hydrolyzed Jojoba Esters would be predicted as EPA Category IV/GHS Category 4-5.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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