Registration Dossier
Registration Dossier
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EC number: 232-167-2 | CAS number: 7789-45-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from HSDB database. Peer reviewed.
- Guideline:
- other: Not specified
- Principles of method if other than guideline:
- Cell volume bioassay
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- No data
- Analytical monitoring:
- not specified
- Details on sampling:
- No data
- Vehicle:
- not specified
- Details on test solutions:
- No data
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- Selenastrum capricornatum (green alga)
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 14 d
- Duration:
- 14 d
- Dose descriptor:
- EC50
- Effect conc.:
- 85 µg/L
- Basis for effect:
- other: Cell volume
- Details on results:
- No further information
- Results with reference substance (positive control):
- No data
- Reported statistics and error estimates:
- No data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In the conditions of a Cell volume bioassay where the toxicity of the substance copper dibromide on the green alga Selenastrum capricornatum was assessed, the 14d-EC50 was determined to be 85 ug/L.
- Executive summary:
In the conditions of a Cell volume bioassay where the toxicity of the substance copper dibromide on the green alga Selenastrum capricornatum was assessed, the 14d-EC50 was determined to be 85 ug/L.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from HSDB database. Peer reviewed.
- Guideline:
- other: Not specified
- Principles of method if other than guideline:
- Growth rate bioassay
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- No data
- Analytical monitoring:
- not specified
- Details on sampling:
- No data
- Vehicle:
- not specified
- Details on test solutions:
- No data
- Test organisms (species):
- other: Thalassiosira pseudonana
- Test type:
- not specified
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 5 µg/L
- Basis for effect:
- growth rate
- Details on results:
- No further information
- Results with reference substance (positive control):
- No data
- Reported statistics and error estimates:
- No data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In the conditions of a growth rate bioassay where the toxicity of the substance copper dibromide in saltwater on Thalassiosira was assessed, the 72h-EC50 was determined to be 5 ug/L.
- Executive summary:
In the conditions of a growth rate bioassay where the toxicity of the substance copper dibromide in saltwater on Thalassiosira was assessed, the 72h-EC50 was determined to be 5 ug/L.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from HSDB database. Peer reviewed.
- Guideline:
- other: Not specified
- Principles of method if other than guideline:
- Growth rate bioassay
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- No data
- Analytical monitoring:
- not specified
- Details on sampling:
- No data
- Vehicle:
- not specified
- Details on test solutions:
- No data
- Test organisms (species):
- Nitzschia sp.
- Details on test organisms:
- Nitschia closterium (alga, saltwater)
- Test type:
- not specified
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 33 µg/L
- Basis for effect:
- growth rate
- Details on results:
- No further information
- Results with reference substance (positive control):
- No data
- Reported statistics and error estimates:
- No data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In the conditions of a growth rate bioassay where the toxicity of the substance copper dibromide on Nitschia closterium in saltwater was assessed, the 96h-EC50 was determined to be 33 ug/L.
- Executive summary:
In the conditions of a growth rate bioassay where the toxicity of the substance copper dibromide on Nitschia closterium in saltwater was assessed, the 96h-EC50 was determined to be 33 ug/L.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from HSDB database. Peer reviewed.
- Guideline:
- other: Not specified
- Principles of method if other than guideline:
- Cell volume bioassay
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- No data
- Analytical monitoring:
- not specified
- Details on sampling:
- No data
- Vehicle:
- not specified
- Details on test solutions:
- No data
- Test organisms (species):
- Chlorella sp.
- Details on test organisms:
- Chlorella stigmatophora (alga, saltwater)
- Test type:
- not specified
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 70 µg/L
- Basis for effect:
- other: cell volume
- Details on results:
- No further information
- Results with reference substance (positive control):
- No data
- Reported statistics and error estimates:
- No data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In the conditions of a cell volume bioassay where the toxicity of the substance copper dibromide on Chlorella stigmatophora in saltwater was assessed, the 21d-EC50 was determined to be 70 ug/L.
- Executive summary:
In the conditions of a cell volume bioassay where the toxicity of the substance copper dibromide on Chlorella stigmatophora in saltwater was assessed, the 21d-EC50 was determined to be 70 ug/L.
Referenceopen allclose all
Description of key information
Several data compiled in the HSDB database were available about the toxicity of copper dibromide on algae:
- EC50 Selenastrum capricornatum (green alga) 85 ug/l/14 days /Cell volume bioassay
- EC50 Thalassiosira pseudonana (alga, saltwater) 5 ug/l/72 hr /Growth rate bioassay
- EC50 Nitschia closterium (alga, saltwater) 33 ug/l/96 hr /Growth rate bioassay
- EC50 Chlorella stigmatophora (alga, saltwater) 70 ug/l/21 days /Cell volume bioassay
In a WoE approach, the most conservative values amongst these data were chosen as key toxicity values:
- EC50 for freshwater algae = 85 ug/L
- EC50 for marine water algae = 5 ug/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 85 µg/L
- EC50 for marine water algae:
- 5 µg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
