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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 March 2018 to 03 April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Key result
- Melting / freezing pt.:
- >= 31.18 - <= 68.69 °C
- Decomposition:
- yes
- Decomp. temp.:
- 148 °C
- Remarks on result:
- other: Atmospheric pressure not specified
- Conclusions:
- Under the conditions of this study, the melting range of the test material was 31.18 to 68.69 °C.
- Executive summary:
The melting point of the test material was investigated in accordance with the standardised guidelines OECD 102 and EU Method A.1, under GLP conditions.
The determination of the melting point of the test material was performed via DSC (differential scanning calorimetry). In all runs an endothermic behaviour was detected. In the first and third measurement a clear melting range peak is visible.
The melting range was determined under these circumstances as: 31.18 °C (304.33 K) to 68.69 °C (341.84 K). A peak maximum was detected with 53.51 °C (326.66 K). The onset values were calculated in a range of 37.68 – 39.97 °C. These values are the results of two independent determinations.
A melting point range has been reported in keeping with the UVCB nature of the test material. No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.
Under the conditions of this study, the melting range of the test material was 31.18 to 68.69 °C.
Reference
Pre-Test for Melting Range
Table 1: Results of the Pre-Test
Observations |
Temperature (°C) |
The test material began to melt |
65 |
The test material completely melted to a yellow-white liquid. Capillary sank down to the bottom. |
86 |
Liquid became clear |
89 |
Liquid completely clear, slightly yellow |
98 |
Some bubbles rising |
134 |
Colour of liquid more yellow, less bubbles |
148 |
Colour of liquid strong yellow, no bubbles anymore |
156 |
Colour of liquid slightly orange |
181 |
Gas burner switched off, colour of liquid getting darker and darker |
190 |
- Decomposition of the test material occurred after melting but before boiling. Decomposition started at approx. 148 °C indicated by colour change.
Security Pre-Test for the DSC Instrument
- The crucible was black coloured and stuck on the ground after reaching a temperature of 420 °C.
- The weight was recorded with 33.68 mg.
- The second crucible was visually unchanged and the weight was recorded with 36.16 mg after heating to 100 °C.
Calibration
- After calibration with indium and zinc the measurement of indium yielded the following values:
Expected melting point: 156.6 ± 1.0 °C; measured melting point: 156.68 °C
Expected energy: 28.45 ± 1.0 J/g; measured energy: 28.69 J/g
Assessment: OK
- The measurement of indium after calibration met the validity criteria.
DSC Measurement of the Test Material
Table 2: Values of DSC Test Material First Determination
|
Temperature (°C) |
|
Melting Range |
Begin |
End |
31.49 |
67.21 |
|
Onset |
37.68 |
|
Peak Maximum |
53.25 |
Table 3: Values of DSC Test Material Second Determination
|
Temperature (°C) |
|
Event Range |
Begin |
End |
25.67 |
60.28 |
- As this measurement showed an odd curve a third measurement with a new crucible was prepared.
Table 4: Values of DSC Test Material Third Determination
|
Temperature (°C) |
|
Melting Range |
Begin |
End |
31.18 |
68.69 |
|
Onset |
39.97 |
|
Peak Maximum |
53.51 |
Observations
- The crucible was visually unchanged after all three measurements.
Interpretation
- In all three runs an endothermic behaviour was detected. In the first and third measurement a clear melting range peak is visible in line with pre-test findings.
- As the peak was wide and flat and not sharp and high like the indium measurement for the beginning of the melting range the start and the end of the event was used for evaluation rather than the onset value. The start and end of the event were evaluated with the Event Mark function of the DSC software.
- As the repetition measurement was not reproducible, the determination was discarded.
Table 5: Summary of Results
Melting Range |
°C |
K |
First Determination |
||
Begin |
31.49 |
304.64 |
End |
67.21 |
340.36 |
Peak Maximum |
53.25 |
326.40 |
Onset |
37.68 |
310.83 |
Repeat Second Determination |
||
Begin |
25.67 |
298.82 |
End |
60.28 |
333.43 |
Third Determination |
||
Begin |
31.18 |
304.33 |
End |
68.69 |
341.84 |
Peak Maximum |
53.51 |
326.66 |
Onset |
39.97 |
313.12 |
Min. |
31.18 |
304.33 |
Max. |
68.69 |
341.84 |
Peak Maximum |
53.51 |
326.66 |
Validity
- As the deviation between the evaluated determinations (onset value) was above 0.5 K a melting range is stated.
Discussion
- The determination of the melting point of the test material was performed via DSC (differential scanning calorimetry).
- In all runs an endothermic behaviour was detected. In the first and third measurement a clear melting range peak is visible.
- Therefore the melting range was determined under these circumstances as: 31.18 °C (304.33 K) to 68.69 °C (341.84 K).
A peak maximum was detected with 53.51 °C (326.66 K).
The onset values were calculated in a range of 37.68 – 39.97 °C.
- These values are the results of two independent determinations.
- A melting point range has been reported in keeping with the UVCB nature of the test material.
- No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.
Description of key information
Under the conditions of this study, the melting range of the test material was 31.18 to 68.69 °C.
Key value for chemical safety assessment
Additional information
The melting point of the test material was investigated in accordance with the standardised guidelines OECD 102 and EU Method A.1, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The determination of the melting point of the test material was performed via DSC (differential scanning calorimetry). In all runs an endothermic behaviour was detected. In the first and third measurement a clear melting range peak is visible.
The melting range was determined under these circumstances as: 31.18 °C (304.33 K) to 68.69 °C (341.84 K). A peak maximum was detected with 53.51 °C (326.66 K). The onset values were calculated in a range of 37.68 – 39.97 °C. These values are the results of two independent determinations.
A melting point range has been reported in keeping with the UVCB nature of the test material. No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.
Under the conditions of this study, the melting range of the test material was 31.18 to 68.69 °C.
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