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EC number: 283-393-3 | CAS number: 84608-82-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Nov 27 - Dec 05, 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Principles of method if other than guideline:
- Flask method with slow stirring
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Landesamt für Umwelt Rheinland-Pfalz
- Type of method:
- flask method
- Water solubility:
- <= 5.41 µg/L
- Temp.:
- 20 °C
- pH:
- >= 6.05 - <= 6.34
- Remarks on result:
- other:
- Remarks:
- the mean at the plateau is stated as range < 0.2 – 5.41 μg/L
Reference
Validation Results
Determination of the test item concentrations in the samples was performed following validation report VB17052201G926.
All validation data are summarised in the following table:
Parameter |
Value |
Unit |
Calibrated Range |
0.1 – 1 |
μg/L |
Linear term / Slope b |
279901.094 |
counts*min /μg/L |
Constant / Intercept a |
-717.920 |
counts*min |
Method Variation Coefficient (Precision) |
8.98 |
% |
Specificity |
was given |
- |
Accuracy in demineralized water |
## |
% |
Stability in demineralized water after 1 d (nominal 100 mg/L) |
49 |
% |
LOD / LOQ in calibration solvent |
0.0108 / 0.0325 |
μg/L |
LOD / LOQ in demineralized water# |
0.0085 / 0.0255 |
μg/L |
The concentration of the test item in solutions was determined during validation using the following equation:
Concentration [mg/L] = (Peak area - a) / b * sensitivity correction factor
Sensitivity correction factor was calculated from QC (quality control) samples.
Sensitivity correction factor = 100 % / QC recovery in %
Freshly prepared QC samples were injected regularly, and the QC recoveries were taken into account as sensitivity correction factors.
Results
The measurements of flasks 1C (day 8) and 2-6 were used for the calculation of the mean.
Flask |
Concentration [μg/L]
|
Total Mean [μg/L]
|
Total Standard Deviation [g/L] (Relative standard deviation RSD [%])
|
1C |
0.34 |
1.07 |
2.14 (199) |
2 |
0.22 |
||
3 |
< 0.22 |
||
4 |
< 0.22 |
||
5 |
5.41 |
||
6 |
0.45 |
On the final sampling day a high concentration range (with relative standard deviation 199%) was detected for the finally measured concentration: 1.07 ± 2.14 μg/L.
This high standard deviation may be due to high measurement uncertainty and to the difficulty to prepare mixtures with similar surface of the test item, which is in contact with the surrounding water and therefore important for the dissolution process. Therefore, the mean at the plateau is stated as < 0.2 – 5.41 μg/L (range of six individual vessels).
During this study the dependency of solubility of the nominal load was tested. No dependency on nominal load was detected.
No observations arousing doubts concerning the accuracy of the results and the validity of the study were made.
Description of key information
The mean at the plateau is stated as range < 0.2 – 5.41 μg/L at 20°C and pH = 6.05 – 6.34 (OECD 105, flask method)
Key value for chemical safety assessment
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.