Registration Dossier
Registration Dossier
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EC number: 203-183-7 | CAS number: 104-19-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1966
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was performed according to accepted scientific methods.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Test material form:
- not specified
- Details on test material:
- No further information available
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- male
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- The product as receive was held in continuous 24-hour contact with the shaved skin
- Duration of exposure:
- 24 hrs
- Doses:
- 0.313, 0.625, 1.25 mL/kg
- No. of animals per sex per dose:
- No data
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.51 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 0.39 - <= 0.67
- Mortality:
- 1.25 mL/kg: 5/5 animals died within 6-24 hrs
0.625 mL/kg: 4/5 animals died (3 animals on day 3, 1 animals on day 5)
0.313 mL/kg: 0/5 animals died - Clinical signs:
- other: signs of intoxication observed: depression
- Gross pathology:
- Gross pathology of surviving animals was performed, and no abnormalities were observed.
- Other findings:
- signs of irritation observed: eschar formation
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- An LD50 value of 0.51 mL/kg was established. The test substance is considered classified as acute dermal toxicant category 4 according to CLP Regulation.
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