Sulfates of potassium, sodium and calcium, byproduct from fermentation

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Read-Across

Justification for type of information:

See attached document below.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Key result

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

1 562 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Key result

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

810 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Conclusions:

Based on a worse case approach,taking into account the highest toxicity to Pseudokirchneriella subcapitata observed with the 3 source substances [Potassium sulfate (CAS 7778-80-5), Sodium sulfate (CAS 7757-82-6) and Calcium sulfate (CAS 7778-18-9)], the 96h-EC50 value of 1562 mg/L and the NOEC = 810 mg/L, was attributed to the target substance “Sulfates of potassium, sodium and calcium, by-product from fermentation”. According to CLP criteria, this substance  is not classified for its toxicity to aquatic algae.

Executive summary:

The results on the toxicity to algae are indicative of a similar very low toxicity of the 3 sulfates salts. The 72h/96h-EC50 to the green algae  Pseudokirchneriella subcapitata  obtained for Potassium sulfate, Sodium sulfate and Calcium sulfate are 3480 mg/L, 1562 mg/L and >2100 mg/L respectively. These extremely high values demonstrate the lack of adverse effects of the 3 source substances to the green algae. No toxicity study to algae is available for the registered substance “Sulfates of potassium, sodium and calcium, by-product from fermentation”. However taking into account the data available on the three sulfate salts, the registered substance is not considered to be hazardous for algae.  Based on a worse case approach, the lowest 96h-EC50 and NOEC on Pseudokirchneriella subcapitata obtained with the 3 sulfate salts, namely 1562 mg/L and 810 mg/L respectively, are  attributed to the target substance “Sulfates of potassium, sodium and calcium, by-product from fermentation” as representative of its toxicity to the green algae. According to CLP criteria, this substance  is not classified for its toxicity to aquatic algae.

Description of key information

Based on a worse case approach,taking into account the highest toxicity to Pseudokirchneriella subcapitata observed with the 3 source substances [Potassium sulfate (CAS 7778-80-5), Sodium sulfate (CAS 7757-82-6) and Calcium sulfate (CAS 7778-18-9)], the 96h-EC50 value of 1562 mg/L and the NOEC = 810 mg/L, was attributed to the target substance “Sulfates of potassium, sodium and calcium, by-product from fermentation”. According to CLP criteria, this substance  is not classified for its toxicity to aquatic algae.

Key value for chemical safety assessment

EC50 for freshwater algae:

1 562 mg/L

EC10 or NOEC for freshwater algae:

810 mg/L

Additional information

The results on the toxicity to algae are indicative of a similar very low toxicity of the 3 sulfates salts. The 72h/96h-EC50 to the green algae  Pseudokirchneriella subcapitata  obtained for Potassium sulfate, Sodium sulfate and Calcium sulfate are 3480 mg/L, 1562 mg/L and >2100 mg/L respectively. These extremely high values demonstrate the lack of adverse effects of the 3 source substances to the green algae. No toxicity study to algae is available for the registered substance “Sulfates of potassium, sodium and calcium, by-product from fermentation”. However taking into account the data available on the three sulfate salts, the registered substance is not considered to be hazardous for algae.  Based on a worse case approach, the lowest 96h-EC50 and NOEC on Pseudokirchneriella subcapitata obtained with the 3 sulfate salts, namely 1562 mg/L and 810 mg/L respectively, are  attributed to the target substance “Sulfates of potassium, sodium and calcium, by-product from fermentation” as representative of its toxicity to the green algae. According to CLP criteria, this substance  is not classified for its toxicity to aquatic algae.