Registration Dossier
Registration Dossier
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EC number: 949-084-9 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Remarks:
- repeat insult test (Buehler)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Source reference not found, but is cited in several handbooks
Data source
Reference
- Reference Type:
- publication
- Title:
- Sensitising properties of indium, palladium and vanadium
- Author:
- Roshchin et al
- Year:
- 1 982
- Bibliographic source:
- Gig. Tr Prof. Zabol 5 - 8 (1982)
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Buehler repeat exposure
- Version / remarks:
- Buehler repeat exposure
- Principles of method if other than guideline:
- Also references 'ear swelling' test, but no details of method in the review documents
- GLP compliance:
- no
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- Historical study that provides a positive response
Test material
- Reference substance name:
- Vanadium oxide sulphate
- EC Number:
- 248-652-7
- EC Name:
- Vanadium oxide sulphate
- Cas Number:
- 27774-13-6
- Molecular formula:
- V(IV) O (SO4)
- IUPAC Name:
- Vanadium IV oxysulphate
Constituent 1
- Specific details on test material used for the study:
- Precise form of vanadium sulphate not specified
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Described as 'albino' guinea pigs
Results and discussion
- Positive control results:
- Non specified
In vivo (non-LLNA)
Results
- Reading:
- other: Not specified
- Group:
- test chemical
- Dose level:
- 3% concentration
- No. with + reactions:
- 80
- Total no. in group:
- 80
- Clinical observations:
- Not specified
- Remarks on result:
- positive indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- Insufficient data to sub-categorise the classification.
The review document also references ear-swelling test on vanadium sulphate as being positive
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