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EC number: 830-086-2 | CAS number: 742087-48-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, 2-hydroxy-3-sulfopropyl ethers, sodium salts did not induce chromosome aberration in Chinese hamster lung fibroblast (CHL) cell with or without S9 metabolic activation.
Bacterial mutagencicity also returned a negative result for this substance.
Supporting data for C10 - 16 alkyl polyglucoside, which is considered to be a suitable read-across material, also found negative results. The genotoxic potential of CIO-16 alkyl polyglucoside (APG) was evaluated in an assay for chromosomal aberrations using Chinese hamster V 79 lung fibroblasts, with and without metabolic activation. C10-16 APG was not clastogenic in this assay.
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test based in official method OCDE 471 , and performed under GLP
- Justification for type of information:
- SugaNate 160NC has been used in this end point as a read-across substance for SugaNate 100NC. A comparison of the two substances and a read-across justification can be found in section 13 of this dataset.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- Principles of method if other than guideline:
- The purpose of this study was to evaluate if the test material would induce a mutagenic response in four different strains of Salmonella (TA98,TA100, TA1335 and TA 1537 ) and E-coli WP2.
The test involves the analysis of the number of revertant colonies that are obtained with each strain in the presence or absence of the test material. Since mutagenic response could vary with the concentration , test material is dosed over an appropriate concentration range (5). Complete set of possitive and negative controls have been included with each assay.
Testing was done with solvent control
All dose levesls of the test material , solvent control and positive controls were plated in triplicate. (Refer to Protocol M09-0093 included in this dossier for the detailed test procedure) - GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
- Target gene:
- (Refer to Protocol M09-0093 included in this dossier for the detailed test procedure)
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- E. coli WP2 uvr A
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- S-9 activation
- Test concentrations with justification for top dose:
- 5.0,1.0,0.5,0.1 and 0.05 micrograme /plate
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Remarks:
- DMSO
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminoantraceno (all strains +s9)
- Remarks:
- See información about material and methods
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
- Conclusions:
- Interpretation of results (migrated information):
negative - Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- SugaNate 160NC has been used in this end point as a read-across substance for SugaNate 100NC. A comparison of the two substances and a read-across justification can be found in section 13 of this dataset.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- GLP compliance:
- not specified
- Remarks:
- Review article did not specify these details
- Type of assay:
- in vitro mammalian chromosome aberration test
- Species / strain / cell type:
- Chinese hamster lung fibroblasts (V79)
- Metabolic activation:
- with and without
- Metabolic activation system:
- at concentrations of <160 microg/mL with and <16 microg/mL without metabolic activation.'
- Species / strain:
- Chinese hamster lung fibroblasts (V79)
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- not applicable
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Conclusions:
- The genotoxic potential of CIO-16 alkyl polyglucoside (APG) was evaluated in an assay for chromosomal aberrations using Chinese hamster V 79 lung fibroblasts, with and without metabolic activation. C10-16 APG was not clastogenic in this assay. Positive and negative controls gave expected results.
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- SugaNate 160NC has been used in this end point as a read-across substance for SugaNate 100NC. A comparison of the two substances and a read-across justification can be found in section 13 of this dataset.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- Version / remarks:
- The Guidelines for the Testing of Chemicals: Health Effects Part [M], Second Edition, China Environmental Press, 2013.
OECD Guideline For The Testing Of Chemicals. TG 473 In Vitro Mammalian Chromosome Aberration Test. OECD, 2014 - Deviations:
- no
- GLP compliance:
- yes
- Type of assay:
- in vitro mammalian chromosome aberration test
- Specific details on test material used for the study:
- Name: D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, 2-hydroxy-3-sulfopropyl ethers, sodium salts
Short name: Sodium Laurylglucosides Hydroxypropylsulfonate
Lot No. : KDM-1021-174
Physical properties: Amber semisolid
Purity: 88.1 %
Valid until: 20 January, 2018
Storage: Room temperature
Manufacturer: Colonial Chemical, Inc. - Species / strain / cell type:
- Chinese hamster lung fibroblasts (V79)
- Remarks:
- Chinese hamster lung fibroblast (CHL) cell.
- Details on mammalian cell type (if applicable):
- Cells were cultured in 96-well plates in a concentration of 8000 cells/well
- Metabolic activation:
- with and without
- Metabolic activation system:
- Cells were exposed to the test substance with S9 metabolic activation for 3 hours, or exposed to the test substance without metabolic activation for 3 h and 24 h.
- Test concentrations with justification for top dose:
- The solubility of D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, 2-hydroxy-3-sulfopropyl ethers, sodium salts in DMSO was 50 mg/mL. In solubility test, each concentration of the test substance was completely dissolved with 0.5 mg/mL as the highest concentration. So, in our cytotoxicity test, 0.5 mg/mL was used as the highest concentration.
D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, 2-hydroxy-3-sulfopropyl ethers, sodium salts 0.5 mg/mL was used as the highest concentration and other 8 lower concentrations were 0.25 mg/mL, 0.125 mg/mL, 0.0625 mg/mL, 0.03125 mg/mL, 0.01563 mg/mL, 0.00781 mg/mL, 0.00391 mg/mL, 0.00195 mg/mL. - Untreated negative controls:
- yes
- Remarks:
- Name: Dimethyl sulfoxide, Short name: DMSO, Lot No.: SHBG6226V Manufacturer: Sigma-Aldrich
- Positive controls:
- yes
- Positive control substance:
- methylmethanesulfonate
- Key result
- Species / strain:
- Chinese hamster lung fibroblasts (V79)
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- Cytotoxicity test showed that IC50 values of test substance were between 0.01563 mg/mL and 0.03125 mg/mL in +S9/3h systems, while it was between 0.007813 mg/mL and 0.01563 mg/mL in -S9/3h systems and -S9/24h systems.
With S9 metabolic activation system, the percentage of aberrant cells in groups treated with D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, 2-hydroxy-3-sulfopropyl ethers, sodium salts were 2.00 %, 2.49 % and 1.49 %, respectively, and the corresponding concentrations were 0.03125 mg/mL, 0.01563 mg/mL and 0.007813 mg/mL. There was no statistical significance compared to vehicle control group (1.50 %).
Without S9 metabolic activation, the percentage of aberrant cells in D-Glucopyranose oligomeric, C10-16-alkyl glycosides, 2-hydroxy-3-sulfopropyl ethers, sodium salts treatment groups for 3h with three concentrations of 0.01563 mg/mL, 0.007813 mg/mL and 0.003906 mg/mL were 1.90 %, 2.44 % and 1.99 %, respectively. There was no statistical significance compared to vehicle control group (1.87 %). Without S9 metabolic activation, the percentage of aberrant cells in D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, 2-hydroxy-3-sulfopropyl ethers, sodium salts treatment groups for 24h with three concentrations of 0.01563 mg/mL, 0.007813 mg/mL and 0.003906 mg/mL were 2.91 %, 1.94 % and 1.50 % respectively. There were no statistical significance compared to vehicle control group (1.99%).
Compared to the vehicle control group, the percentage of aberrant cells in groups treated with positive control Cyclophosphamide (25 μg/mL) in +S9/3h systems was 12.50 % (P<0.001), Methyl Methanesulfonate (0.25 μg/mL) in -S9/3h and -S9/24h were 11.44 % (P<0.001) and 11.50 % (P<0.001). - Conclusions:
- D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, 2-hydroxy-3-sulfopropyl ethers, sodium salts (Lot No.: KDM-1021-174) did not induce chromosome aberration in Chinese hamster lung fibroblast (CHL) cell with or without S9 metabolic activation.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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