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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Since hexadecanoic anhydride decomposes to hexadecanoic acid when administered via oral route, only hexadecanoic acid was considered for the assessment of the acute toxicity.
Based on available study results, hexadecanoic acid results not toxic via oral route, therefore also the test item doesn't meet the GHS criteria for the classifcation as oral toxic and is considered not toxic via oral route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Guideline:
- other: information not available
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Commercial grade
- Species:
- rat
- Details on test animals or test system and environmental conditions:
- Albino rats
- Route of administration:
- oral: gavage
- Doses:
- Administration of doses up to 10.0 g/Kg
- Key result
- Dose descriptor:
- other: information not available
- Remarks on result:
- other: Transient signs of toxicity observed in rats of the higher dose groups of 4.64 and 10.0 g/Kg Palmitic acid
- Mortality:
- Administration of doses up to 10.0 g/Kg Palmitic Acid resulted in no deaths
- Clinical signs:
- other: Transient signs of toxicity observed in rats of the higher dose groups of 4.64 and 10.0 g/Kg Palmitic acid. Signs of toxicity included slight CNS/depression, depressed righting and placement reflexes, oily and unkempt flur, mucoid diarrhea, excessive sali
- Gross pathology:
- Administration of doses up to 10.0 g/Kg Palmitic Acid resulted in no significant gross lesions at necroscopy
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Administration of doses up to 10.0 g/Kg Palmitic Acid by galvage to albino rats resulted in no deaths and no significant gross lesions at necroscopy. Transient signs of toxicity were observed in rats of the higher dose groups of 4.64 and 10.0 g/Kg Palmitic acid. Signs of toxicity included slight CNS/depression, depressed righting and placement reflexes, oily and unkempt flur, mucoid diarrhea, excessive salivation and serosanguineous discharge from the muzzle and eyes.
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Since the test item is a reaction mass of hexadecanoic anhydride and hexadecanoic acid, hexadecanoic acid was used for the read-across.
- Reason / purpose for cross-reference:
- read-across source
- Guideline:
- other: information not available
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Commercial grade
- Species:
- rat
- Details on test animals or test system and environmental conditions:
- Albino rats
- Route of administration:
- oral: gavage
- Doses:
- Administration of doses up to 10.0 g/Kg
- Key result
- Dose descriptor:
- other: information not available
- Remarks on result:
- other: Transient signs of toxicity observed in rats of the higher dose groups of 4.64 and 10.0 g/Kg Palmitic acid
- Mortality:
- Administration of doses up to 10.0 g/Kg Palmitic Acid resulted in no deaths
- Clinical signs:
- other: Transient signs of toxicity observed in rats of the higher dose groups of 4.64 and 10.0 g/Kg Palmitic acid. Signs of toxicity included slight CNS/depression, depressed righting and placement reflexes, oily and unkempt flur, mucoid diarrhea, excessive sali
- Gross pathology:
- Administration of doses up to 10.0 g/Kg Palmitic Acid resulted in no significant gross lesions at necroscopy
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Administration of doses up to 10.0 g/Kg Palmitic Acid by galvage to albino rats resulted in no deaths and no significant gross lesions at necroscopy. Transient signs of toxicity were observed in rats of the higher dose groups of 4.64 and 10.0 g/Kg Palmitic acid. Signs of toxicity included slight CNS/depression, depressed righting and placement reflexes, oily and unkempt flur, mucoid diarrhea, excessive salivation and serosanguineous discharge from the muzzle and eyes.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Guideline:
- other: information not available
- GLP compliance:
- not specified
- Remarks:
- Information not available
- Species:
- rat
- Route of administration:
- oral: unspecified
- Key result
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the test result (LD50 Rat oral >10000 mg/kg), hexadecanoic acid is not considered toxic via oral route.
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- Since the test item is a reaction mass of hexadecanoic anhydride and hexadecanoic acid, hexadecanoic acid was used for the read-across.
- Reason / purpose for cross-reference:
- read-across source
- Guideline:
- other: information not available
- GLP compliance:
- not specified
- Remarks:
- Information not available
- Species:
- rat
- Route of administration:
- oral: unspecified
- Key result
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the test result (LD50 Rat oral >10000 mg/kg), hexadecanoic acid is not considered toxic via oral route.
Referenceopen allclose all
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.