Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-445-3 | CAS number: 8030-70-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-02-13 to 2019-04-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- Three vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- yes
- Remarks:
- Three vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed, 2016-05-31
- Type of method:
- flask method
- Specific details on test material used for the study:
- Appearance: highly viscous, sticky, brown
Storage conditions: Keep in a dry and well-ventilated place in tightly sealed original container. Do not store in heat or direct sunlight. - Water solubility:
- 22.5 mg/L
- Conc. based on:
- element
- Remarks:
- Mn
- Loading of aqueous phase:
- 800 mg/L
- Incubation duration:
- 39 d
- Temp.:
- 20.1 °C
- pH:
- >= 6.3 - <= 7.1
- Remarks on result:
- other: S.D.: ± 7.3 mg Mn/L
- Key result
- Water solubility:
- 265 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 800 mg/L
- Incubation duration:
- 39 d
- Temp.:
- 20.1 °C
- pH:
- >= 6.3 - <= 7.1
- Remarks on result:
- other: S.D.: ± 86 mg/L
- Remarks:
- calculated based on a Mn content of 8.5%
- Details on results:
- Temperature:
The mean temperatures were 20.1 ± 0.2 °C (data logger 2) and 19.8 ± 0.1 °C (data logger 7). The maximum and minimum temperature was 19.7 °C and 22.0 °C, respectively. An increasing temperature for a short time (i.e., one hour) is considered to be not critical and had no influence on the result of the water solubility of the test substance. Moreover, the mean temperature was within the limits.
pH values
The pH of test item solutions was in the range of 6.3 – 7.1, whereas the pH of method blanks was in the range of 5.9 - 7.3.
Turbidity
The turbidity in samples from test was always < 1 NTU indicating that filtered test item solutions did not contain any undissolved material after filtering.
Turbidity measurements were not performed on days 37, 38 and 39 due to insufficient test solution.
This is not critical and does not influence the result of the determination of the water solubility for the test item.
Analytical measurements
Manganese concentrations in method blanks were analysed / calculated if at least one sample per sampling day was >LOQ. Hence, the background concentrations (< 1 µg/L) are far below concentrations in actual samples (at least > 5 mg/L) a background correction was not necessary.
The increase of concentrations from day 15 to end of testing (day 39) was less than 15 %. Thus, the validity criteria as foreseen in OECD 105 and Regulation 440/2008/EC A.6 were fulfilled.
However, an easy rise of the manganese concentration was observed till end of testing. Nevertheless, after 15 sampling points (39 days) the residual volume in test vessels did not allow any further samplings. - Conclusions:
- Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of ~800 mg/L test item in three replicates), a solubility equilibrium was not reached after day 39 of testing. The mean measured dissolved manganese concentration on day 39 at 20.1 ± 0.2 °C is 22.5 ± 7.3 mg/L.
This corresponds to a water solubility of dissolved Fatty acids, tall-oil, manganese salts of 265 ± 86 mg/L, calculated on a mean manganese content of 8.5 %.
Reference
ICP-OES measurement with corresponding LOD/LOQ, correlation coefficient and sum of quality assurance samples and recovery
Calibration [µg/L] – lowest and highest calibration point |
Chosen wavelength |
LOD |
LOQ |
Correlation coefficient |
Sum of quality assurance samples |
Recovery of quality assurance samples [%] |
February 19, 2018; measurement of samples from 1st preliminary test under non GLP conditions |
||||||
1.0 – 1000 (total of 13 calibration points, 13 used + blank) |
259.372 |
0.035 |
0.106 |
0.999947 |
20 |
100 |
February 25, 2019; measurement of samples from 2nd preliminary test |
||||||
1.0 – 1000 (total of 13 calibration points, 13 used + blank) |
260.568 |
0.166 |
0.498 |
0.999982 |
8 |
100 |
ICP-OES Recovery/validation data manganese of measurement series
Element Mn |
Recovery [%] |
SD [%] |
n (total) |
n (valid) |
February 19, 2018 (1st preliminary test under non GLP conditions) |
||||
Roth 75 µg/L |
105 |
1 |
4 |
4 |
TMDA-70.2 nominal value 312 µg/L Diluted 10-fold nominal value 31.2 µg/L |
102 |
2 |
4 |
4 |
Recalibration standard 250 µg/L |
101 |
1 |
4 |
4 |
TMDA-70.2 nominal value 312 µg/L |
109 |
1 |
4 |
4 |
Roth 750 µg/L |
102 |
1 |
4 |
4 |
February 25, 2019 (2ndpreliminary test) |
||||
Recalibration standard 25 µg/L |
100 |
<1 |
2 |
2 |
Roth 50 µg/L |
99.2 |
0.5 |
2 |
2 |
Recalibration standard 250 µg/L |
98.7 |
0.1 |
2 |
2 |
Roth 500 µg/L |
95.4 |
0.7 |
2 |
2 |
ICP-MS measurement series (March 08, 2019) with corresponding LOD/LOQ, correlation coefficient and sum of quality assurance samples and recovery
Calibration [µg/L] – lowest and highest calibration point |
Chosen isotope |
LOD |
LOQ |
Correlation coefficient |
Sum of quality assurance samples |
Recovery of quality assurance samples [%] |
March 08, 2019; measurement of test samples and method blanks (days 1, 2, 3) |
||||||
0.1 – 250 (total of 14 calibration points, 14 used + blank) |
55Mn in high helium mode |
0.003 |
0.009 |
0.9999 |
33 |
100 |
March 22, 2019; measurement of test samples and method blanks (days 15, 16, 17) |
||||||
0.25 – 500 (total of 14 calibration points, 14 used + blank) |
55Mn in no gas mode |
0.003 |
0.008 |
1.000 |
33 |
100 |
March 29, 2019; measurement of test samples and method blanks (days 23, 24, 25) |
||||||
1.0 – 500 (total of 11 calibration points, 11 used + blank) |
55Mn in high helium mode |
0.005 |
0.015 |
0.9998 |
19 |
100 |
April 08, 2019; measurement of test samples and method blanks (days 30, 31, 32) |
||||||
1.0 – 500 (total of 11 calibration points, 11 used + blank) |
55Mn in helium mode |
0.005 |
0.016 |
1.000 |
19 |
100 |
April 16, 2019; measurement of test samples and method blanks (days 37, 38, 39) |
||||||
1.0 – 500 (total of 11 calibration points, 11 used + blank) |
55Mn in helium mode |
0.005 |
0.015 |
1.000 |
19 |
100 |
ICP-MS Recovery/validation data manganese of measurement series
Element Mn |
Recovery [%] |
SD [%] |
n (total) |
n (valid) |
March 08, 2019 |
||||
LabKings 0.75 µg/L |
99.4 |
2.0 |
6 |
6 |
LabKings 7.5 µg/L |
97.2 |
1.5 |
6 |
6 |
LabKings 75 µg/L |
99.2 |
2.0 |
6 |
6 |
Recalibration standard 10 µg/L |
104 |
2 |
6 |
6 |
Recalibration standard 100 µg/L |
103 |
2 |
6 |
6 |
March 22, 2019 |
||||
LabKings 2.5 µg/L |
105 |
2 |
6 |
6 |
LabKings 25 µg/L |
110 |
3 |
6 |
6 |
LabKings 250 µg/L |
108 |
3 |
6 |
6 |
Recalibration standard 10 µg/L |
109 |
3 |
6 |
6 |
Recalibration standard 100 µg/L |
108 |
4 |
6 |
6 |
March 29, 2019 |
||||
LabKings 25 µg/L |
102 |
1 |
4 |
4 |
Recalibration standard 75 µg/L |
100 |
1 |
4 |
4 |
TMDA-70.2 nominal value 312 µg/L - diluted 2-fold nominal value 156 µg/L |
106 |
1 |
4 |
4 |
LabKings 250 µg/L |
103 |
<1 |
4 |
4 |
April 08, 2019 |
||||
LabKings 25 µg/L |
104 |
2 |
4 |
4 |
Recalibration standard 75 µg/L |
101 |
1 |
4 |
4 |
TMDA-70.2 nominal value 312 µg/L - diluted 2-fold nominal value 156 µg/L |
105 |
1 |
4 |
4 |
LabKings 250 µg/L |
103 |
2 |
4 |
4 |
April 16, 2019 |
|
|
|
|
LabKings 25 µg/L |
106 |
1 |
4 |
4 |
Recalibration standard 75 µg/L |
101 |
1 |
4 |
4 |
TMDA-70.2 nominal value 312 µg/L - diluted 2-fold nominal value 156 µg/L |
107 |
1 |
4 |
4 |
LabKings 250 µg/L |
108 |
2 |
4 |
4 |
ICP-MS Fortification of measurement series
Sample |
Element |
Measured concen-tration [µg/L] |
Calculated level after addition [µg/L] |
Recovery [µg/L] / [%] |
March 08, 2019 |
||||
Vessel 3 sample a 1d (dilution 100-fold) – 1 mL sample, 4 mL 250 µg/L standard |
Mn |
158 |
232 |
247 / 107 |
Vessel 5 sample a 2d (dilution 100-fold) – 1 mL sample, 4 mL 100 µg/L standard |
Mn |
132 |
106 |
106 / 99.4 |
Vessel 3 sample a 3d (dilution 100-fold) – 1 mL sample, 4 mL 75 µg/L standard |
Mn |
174 |
94.9 |
92.4 / 97.4 |
March 22, 2019 |
||||
Vessel 3 sample a 15d (dilution 100-fold) – 1 mL sample, 4 mL 500 µg/L standard |
Mn |
198 |
440 |
439 / 99.9 |
Vessel 5 sample a 16d (dilution 100-fold) – 1 mL sample, 4 mL 500 µg/L standard |
Mn |
182 |
436 |
444 / 102 |
Vessel 4 sample a 17d (dilution 100-fold) – 1 mL sample, 4 mL 250 µg/L standard |
Mn |
85.4 |
217 |
225 / 103 |
March 29, 2019 |
||||
Vessel 3 sample a 23d (dilution 100-fold) – 1 mL sample, 4 mL 500 µg/L standard |
Mn |
222 |
444 |
430 / 96.8 |
Vessel 4 sample a 24d (dilution 100-fold) – 1 mL sample, 4 mL 250 µg/L standard |
Mn |
89.6 |
218 |
218 / 99.9 |
Vessel 5 sample a 25d (dilution 100-fold) – 1 mL sample, 4 mL 100 μg/L standard |
Mn |
196 |
119 |
120 / 101 |
April 08, 2019 |
||||
Vessel 3 sample a 23d (dilution 100-fold) – 1 mL sample, 4 mL 500 µg/L standard |
Mn |
235 |
447 |
465 / 104 |
Vessel 4 sample a 24d (dilution 100-fold) – 1 mL sample, 4 mL 250 µg/L standard |
Mn |
104 |
221 |
220 / 99.6 |
Vessel 5 sample a 25d (dilution 100-fold) – 1 mL sample, 4 mL 100 µg/L standard |
Mn |
235 |
127 |
129 / 102 |
April 16, 2019 |
||||
Vessel 3 sample a 37d (dilution 100-fold) – 1 mL sample, 4 mL 500 µg/L standard |
Mn |
288 |
458 |
463 / 101 |
Vessel 4 sample a 38d (dilution 100-fold) – 1 mL sample, 4 mL 250 µg/L standard |
Mn |
126 |
225 |
224 / 99.4 |
Vessel 5 sample a 39d (dilution 100-fold) – 1 mL sample, 4 mL 100 µg/L standard |
Mn |
254 |
131 |
131 / 99.8 |
The water solubility of the test item is 265 mg/L ± 86 mg/L at day 39 based on a measured manganese concentration of 22.5 ± 7.3 mg Mn/L
Mean Mn concentrations
Vessel 3: 28.9 ±
0.2 mg/L Mn
Vessel 4: 13.3 ±
< 0.1 mg/L Mn
Vessel 5: 25.3 ±
0.2 mg/L Mn
Mean: 22.5
± 6.7 mg/L Mn
The mean Mn concentrations in replicate vessel 4 differ.
Based on a test item purity of 100 % and a mean manganese content of 8.5 % the water solubility ofthe test item is:
Mean of concentration x 100 % / 8.5 %
Vessel 3: 340 ±
3 mg/L test item
Vessel 4: 156 ±
< 1 mg/L test item
Vessel 5: 297 ±
2 mg/L test item
Mean: 265
± 86 mg/L test item
Description of key information
Fatty acids, tall-oil, manganese salts has a water solubility of 265 ± 86 mg/L, calculated on a mean manganese content of 8.5 %.
Key value for chemical safety assessment
- Water solubility:
- 265 mg/L
- at the temperature of:
- 20 °C
Additional information
Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of ~800 mg/L test item in three replicates), a solubility equilibrium was not reached after day 39 of testing. The mean measured dissolved manganese concentration on day 39 at 20.1 ± 0.2 °C is 22.5 ± 7.3 mg/L.
This corresponds to a water solubility of dissolved Fatty acids, tall-oil, manganese salts of 265 ± 86 mg/L, calculated on a mean manganese content of 8.5 %.
The dissolution of manganese from Fatty acids, tall-oil manganese salts after 2h in simulated gastric acid (pH 1.5) at 0.2 and 2 g/L loading is 2.2 and 1.2%, respectively, corresponding to 0.401 and 2.14 mg Mn/L.
The dissolution of Mn in simulated interstitial fluid (pH 7.4) at a loading of 2 g/L Fatty acids, tall-oil manganese salts is 0.16 and 1.5% after 24h and 168h, respectively, corresponding to 0.291 and 2.74 mg Mn/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.