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EC number: 244-543-3 | CAS number: 21722-83-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-cyclohexylethyl acetate
- EC Number:
- 244-543-3
- EC Name:
- 2-cyclohexylethyl acetate
- Cas Number:
- 21722-83-8
- Molecular formula:
- C10H18O2
- IUPAC Name:
- 2-cyclohexylethyl acetate
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- The primary stock solution used in the range-finding test was prepared by dissolving 10 mg of the
test substance in 40 mL of dilution water — M4 and the total volume was completed to 100 mL,
resulting in a concentration of 100 mg.L-1. The secondary stock solutions of the 10; 1 and 0,1
mg.L-lwere prepared by dilutions of the primary stock solution.
The primary stock solution used in the definitive test was prepared by dissolving 50 mg of the test
substance in 40 mL of dilution water — M4 and the total volume was completed to 500 mL,
resulting in a concentration of 100 mg.L-1.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The test system used for this study is described below, according to Straus (1820):
Kingdom: Animalia
Phylum: Arthropoda
Subphylum: Crustacea
Class: Branchiopoda
Order: Cladocera
Family: Daphniidae
Genus: Daphnia
Species: Daphnia magna
Young Daphnia magna 5 24 hours old were obtained from the culture kept at the Ecotoxicology
Laboratory, maintenance and cultivation records are archived at BIOAGRI.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 196.7 mg.L-1 CaCO3
- Test temperature:
- 20.1°C
- pH:
- 7.7
- Dissolved oxygen:
- 8.0 mg.L-1
- Details on test conditions:
- In each culture container 30 organisms were maintained daily. They were daily fed with algae
suspension (Pseudokirchneriella subcapitata) with 107 cells.organisms-1. The water of each
culture was renewed twice a week (Mondays and Thursdays). - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate (K2Cr2O7)
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 36.82 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mortality
- Details on results:
- The 24 and 48-hours EC50 values of the product Cyclohexyl Ethyl Acetate were 50.00 mg.L-1 (95%
confidence limits = 34.76 to 71.92 mg.L-1) and 36.82 mg.L-1 (95% confidence limits = 30.08 to 45.07
mg.L-1), respectively.
In the definitive test the highest tested concentration that did not cause acute effect (immobility)
to the organisms after 48 hours was 13 mg.L-1. The lowest concentration that caused 100%
immobility was 100 mg.L-1. - Results with reference substance (positive control):
- The 24-hours EC50 value of the reference substance (potassium dichromate) was 1.05 mg.L-1 (95%
confidence limits = 0.91 to 1.21 mg.L-1), showing the sensitivity of the test system (ISO 6341 /
OECD 202, 2004).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-hours EC50 value of Cyclohexyl Ethyl Acetate was 36.82 mg.L-1 (95% confidence limits = 30.08 to 45.07 mg.L-1).
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